Synthetic RNA and DNA Polynucleotides: In Vivo and in Vitro Enhancement of Oncogenesis by a Murine Sarcoma Virus

A. F. Gazdar, Y. Ikawa

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Pretreatment with the synthetic polynucleotides rl·rC, rA·rU, d(A-T), dG·dC, rA·dT and dT enhanced tumor induction in mice by the Moloney strain of murine sarcoma virus (MSV), but pretreatment with rl, rC, rA·rU·rU and calf thymus DNA had no effect. In addition, pretreatment with rI·rC and d(A-T) enhanced focus formation by MSV 10–30 fold in mouse tissue culture cells. A correlation may exist between the MSV enhancing and the antiviral properties of polynucleotides. Note added in press: Preliminary characterization of the antiviral substance induced by d(A-T) indicates that its properties are not similar to those of mouse interferon (A.F. G. and S. Baron, unpublished observations).

Original languageEnglish (US)
Pages (from-to)1166-1169
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume140
Issue number4
DOIs
StatePublished - Sep 1972

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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