Synthetic Studies on the Kigamicins

Ai Jun Ma; Joseph M. Ready

doi:10.1021/acs.orglett.9b00098

Synthetic Studies on the Kigamicins

Ai Jun Ma, Joseph M. Ready

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.

Original language	English (US)
Pages (from-to)	1148-1151
Number of pages	4
Journal	Organic Letters
Volume	21
Issue number	4
DOIs	https://doi.org/10.1021/acs.orglett.9b00098
State	Published - Feb 15 2019
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.9b00098

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abstract = "The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.",

author = "Ma, {Ai Jun} and Ready, {Joseph M.}",

note = "Funding Information: Funding provided by the Welch Foundation (I-1612) and the Petroleum Research Fund (58264-ND1).",

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AU - Ready, Joseph M.

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Y1 - 2019/2/15

N2 - The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.

AB - The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.

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Synthetic Studies on the Kigamicins

Abstract

ASJC Scopus subject areas

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