Abstract
The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.
| Original language | English (US) |
|---|---|
| Journal | Organic Letters |
| DOIs | |
| State | Published - Jan 1 2019 |
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ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Cite this
Synthetic Studies on the Kigamicins. / Ma, Ai Jun; Ready, Joseph M.
In: Organic Letters, 01.01.2019.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Synthetic Studies on the Kigamicins
AU - Ma, Ai Jun
AU - Ready, Joseph M
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.
AB - The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.
UR - http://www.scopus.com/inward/record.url?scp=85061266237&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061266237&partnerID=8YFLogxK
U2 - 10.1021/acs.orglett.9b00098
DO - 10.1021/acs.orglett.9b00098
M3 - Article
C2 - 30714741
AN - SCOPUS:85061266237
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
ER -