Synthetic Studies on the Kigamicins

Ai Jun Ma, Joseph M Ready

Research output: Contribution to journalArticle

Abstract

The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.

Original languageEnglish (US)
JournalOrganic Letters
DOIs
StatePublished - Jan 1 2019

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Biological Products
Poisons
Cyclization
nutrients
products
sugars
musculoskeletal system
Skeleton
Sugars
Hydration
Nutrients
hydration
cancer
Cells
Food
synthesis
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Synthetic Studies on the Kigamicins. / Ma, Ai Jun; Ready, Joseph M.

In: Organic Letters, 01.01.2019.

Research output: Contribution to journalArticle

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