Synthetic Studies on the Kigamicins

Ai Jun Ma, Joseph M Ready

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.

Original languageEnglish (US)
JournalOrganic Letters
DOIs
StatePublished - Jan 1 2019

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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