Synthetic Studies on the Kigamicins

Ai Jun Ma; Joseph M Ready

doi:10.1021/acs.orglett.9b00098

Synthetic Studies on the Kigamicins

Ai Jun Ma, Joseph M Ready

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.

Original language	English (US)
Journal	Organic Letters
DOIs	https://doi.org/10.1021/acs.orglett.9b00098
State	Published - Jan 1 2019

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Synthetic Studies on the Kigamicins",

abstract = "The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.",

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