Systemic Chemotherapy For Psoriasis: A National Survey

P. R. Bergstresser, S. H. Schreiber, G. D. Weinstein

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


A questionnaire that was mailed to 510 randomly selected dermatologists in the United States surveyed their use of three systemic chemotherapeutic agents for the treatment of psoriasis during the two-year period of 1973 to 1974. Methotrexate was used by 52% of the surveyed dermatologists, while hydroxyurea and azaribine were used by 10% and 2%, respectively. Seventy-five percent of the dermatologists who used methotrexate treated ten or fewer psoriatic patients with this drug. Multiple dose therapy with methotrexate divided over a period of 36 hours each week was the preferred schedule of 66% of the dermatologists. Liver biopsy specimens and creatinine clearance tests were obtained for only 17% and 35% of patients, respectively, prior to initiating methotrexate therapy. The estimated number of dermatologisttreated psoriatics nationwide receiving methotrexate is 25,000.

Original languageEnglish (US)
Pages (from-to)977-981
Number of pages5
JournalArchives of Dermatology
Issue number7
StatePublished - Jul 1976

ASJC Scopus subject areas

  • Dermatology


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