Systemic cytokine profile in children with community-acquired pneumonia

Ian C. Michelow, Kathy Katz, George H. McCracken, R. Doug Hardy

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objectives: Characterization of the systemic cytokine response in community-acquired pneumonia (CAP) may facilitate our understanding of the host immune response and provide a prognostic as well as diagnostic tool. Systemic cytokine characterization of CAP has been limited largely to a few integral cytokines in adults. Methods: Analyses were performed to investigate whether significant relationships existed between an expanded serum cytokine profile and etiologies, manifestations, and outcomes of pediatric CAR The serum concentrations of 15 cytokines were investigated in 55 hospitalized children with well-characterized CAP Results: Comparison of median cytokine concentrations among patients with CAP caused by Mycoplasma pneumoniae or Chlamydophila pneumoniae, Streptococcus pneumoniae, viruses, mixed infections, or unidentified pathogens revealed significant differences in IFN-α, IL-6, IL-17, GM-CSF, and TNF-α concentrations. The mixed infections category had significantly elevated concentrations of IFN-α, IL-6, GM-CSF, and TNF-α. There were significant correlations between concentrations of IL-6 and markers of disease severity (white blood cell band-forms, procalcitonin, and unequivocal consolidation). No single cytokine could reliably differentiate the etiologic cause of pneumonia. Conclusions: IL-6 is the only one of 15 serum cytokines studied that correlated with indicators of disease severity in childhood CAP The applicability of cytokine profiles to identify microbiologic etiologies of pneumonia remains to be defined.

Original languageEnglish (US)
Pages (from-to)640-645
Number of pages6
JournalPediatric Pulmonology
Volume42
Issue number7
DOIs
StatePublished - Jul 2007

Fingerprint

Pneumonia
Cytokines
Interleukin-6
Granulocyte-Macrophage Colony-Stimulating Factor
Coinfection
Serum
Chlamydophila pneumoniae
Mycoplasma pneumoniae
Hospitalized Child
Interleukin-17
Calcitonin
Virus Diseases
Streptococcus pneumoniae
Leukocytes
Pediatrics

Keywords

  • Children
  • Cytokine
  • IL-6
  • Mycoplasma pneumoniae
  • Pediatric
  • Pneumonia
  • Streptococcus pneumoniae
  • Wheeze

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Systemic cytokine profile in children with community-acquired pneumonia. / Michelow, Ian C.; Katz, Kathy; McCracken, George H.; Hardy, R. Doug.

In: Pediatric Pulmonology, Vol. 42, No. 7, 07.2007, p. 640-645.

Research output: Contribution to journalArticle

Michelow, Ian C. ; Katz, Kathy ; McCracken, George H. ; Hardy, R. Doug. / Systemic cytokine profile in children with community-acquired pneumonia. In: Pediatric Pulmonology. 2007 ; Vol. 42, No. 7. pp. 640-645.
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