Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns

Camilia R. Martin; Melissa Bellomy; Elizabeth N. Allred; Raina N. Fichorova; Alan Leviton

doi:10.3109/15513815.2012.721477

Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns

Camilia R. Martin, Melissa Bellomy, Elizabeth N. Allred, Raina N. Fichorova, Alan Leviton

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

To define the role of systemic inflammation in infants with intestinal perforation (IP) and necrotizing enterocolitis (NEC), we measured 25 blood protein concentrations on days 1, 7 and 14 in 939 infants born before 28 weeks' gestation. On days 7 and 14, infants with NEC had elevated levels of C-reactive protein (CRP), serum amyloid A (SAA), IL-6 and IL-8. Infants with IP had elevated levels of CRP and insulin growth factor binding protein-1 on day 7 and elevated CRP, SAA, TNF-receptor-2 and matrix metalloproteinase-9 levels on day 14. A better understanding of systemic inflammation might help prevent and treat these disorders.

Original language	English (US)
Pages (from-to)	222-234
Number of pages	13
Journal	Fetal and Pediatric Pathology
Volume	32
Issue number	3
DOIs	https://doi.org/10.3109/15513815.2012.721477
State	Published - Jun 2013
Externally published	Yes

Keywords

Cytokines
Infant
Intestinal perforation
Necrotizing enterocolitis
Premature

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pathology and Forensic Medicine

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10.3109/15513815.2012.721477

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title = "Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns",

abstract = "To define the role of systemic inflammation in infants with intestinal perforation (IP) and necrotizing enterocolitis (NEC), we measured 25 blood protein concentrations on days 1, 7 and 14 in 939 infants born before 28 weeks' gestation. On days 7 and 14, infants with NEC had elevated levels of C-reactive protein (CRP), serum amyloid A (SAA), IL-6 and IL-8. Infants with IP had elevated levels of CRP and insulin growth factor binding protein-1 on day 7 and elevated CRP, SAA, TNF-receptor-2 and matrix metalloproteinase-9 levels on day 14. A better understanding of systemic inflammation might help prevent and treat these disorders.",

keywords = "Cytokines, Infant, Intestinal perforation, Necrotizing enterocolitis, Premature",

author = "Martin, {Camilia R.} and Melissa Bellomy and Allred, {Elizabeth N.} and Fichorova, {Raina N.} and Alan Leviton",

note = "Funding Information: None of the authors has any financial issue or conflict of interest to disclose. This study was supported by a cooperative agreement with the National Institute of Neurological Diseases and Stroke (5U01NS040069-05) and a center grant from the National Institute of Child Health and Human Development (5P30HD018655-28).",

year = "2013",

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doi = "10.3109/15513815.2012.721477",

language = "English (US)",

volume = "32",

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AU - Martin, Camilia R.

AU - Bellomy, Melissa

AU - Allred, Elizabeth N.

AU - Fichorova, Raina N.

AU - Leviton, Alan

N1 - Funding Information: None of the authors has any financial issue or conflict of interest to disclose. This study was supported by a cooperative agreement with the National Institute of Neurological Diseases and Stroke (5U01NS040069-05) and a center grant from the National Institute of Child Health and Human Development (5P30HD018655-28).

PY - 2013/6

Y1 - 2013/6

N2 - To define the role of systemic inflammation in infants with intestinal perforation (IP) and necrotizing enterocolitis (NEC), we measured 25 blood protein concentrations on days 1, 7 and 14 in 939 infants born before 28 weeks' gestation. On days 7 and 14, infants with NEC had elevated levels of C-reactive protein (CRP), serum amyloid A (SAA), IL-6 and IL-8. Infants with IP had elevated levels of CRP and insulin growth factor binding protein-1 on day 7 and elevated CRP, SAA, TNF-receptor-2 and matrix metalloproteinase-9 levels on day 14. A better understanding of systemic inflammation might help prevent and treat these disorders.

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KW - Cytokines

KW - Infant

KW - Intestinal perforation

KW - Necrotizing enterocolitis

KW - Premature

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Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns

Abstract

Keywords

ASJC Scopus subject areas

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