Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns

Camilia R. Martin, Melissa Bellomy, Elizabeth N. Allred, Raina N. Fichorova, Alan Leviton

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

To define the role of systemic inflammation in infants with intestinal perforation (IP) and necrotizing enterocolitis (NEC), we measured 25 blood protein concentrations on days 1, 7 and 14 in 939 infants born before 28 weeks' gestation. On days 7 and 14, infants with NEC had elevated levels of C-reactive protein (CRP), serum amyloid A (SAA), IL-6 and IL-8. Infants with IP had elevated levels of CRP and insulin growth factor binding protein-1 on day 7 and elevated CRP, SAA, TNF-receptor-2 and matrix metalloproteinase-9 levels on day 14. A better understanding of systemic inflammation might help prevent and treat these disorders.

Original languageEnglish (US)
Pages (from-to)222-234
Number of pages13
JournalFetal and Pediatric Pathology
Volume32
Issue number3
DOIs
StatePublished - Jun 2013
Externally publishedYes

Keywords

  • Cytokines
  • Infant
  • Intestinal perforation
  • Necrotizing enterocolitis
  • Premature

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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