Systemic iron metabolism and mortality from Parkinson's disease

K. Marder; G. Logroscino; M. X. Tang; J. Graziano; L. Cote; E. Louis; B. Alfaro; H. Mejia; V. Slavkovich; R. Mayeux

doi:10.1212/WNL.50.4.1138

Systemic iron metabolism and mortality from Parkinson's disease

K. Marder, G. Logroscino, M. X. Tang, J. Graziano, L. Cote, E. Louis, B. Alfaro, H. Mejia, V. Slavkovich, R. Mayeux

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13 Scopus citations

Abstract

Six measures of systemic iron metabolism were used to predict mortality among 103 patients with Parkinson's disease and 353 controls followed in a longitudinal study. Adjusting for gender, education, ethnicity, presence of dementia, and extrapyramidal signs, transferrin receptor concentration was strongly associated with mortality in patients with PD but not controls. This increase in serum transferrin receptor concentration before death suggests that the previously observed perturbation in iron metabolism continues throughout the disease course.

Original language	English (US)
Pages (from-to)	1138-1140
Number of pages	3
Journal	Neurology
Volume	50
Issue number	4
DOIs	https://doi.org/10.1212/WNL.50.4.1138
State	Published - Apr 1998
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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abstract = "Six measures of systemic iron metabolism were used to predict mortality among 103 patients with Parkinson's disease and 353 controls followed in a longitudinal study. Adjusting for gender, education, ethnicity, presence of dementia, and extrapyramidal signs, transferrin receptor concentration was strongly associated with mortality in patients with PD but not controls. This increase in serum transferrin receptor concentration before death suggests that the previously observed perturbation in iron metabolism continues throughout the disease course.",

author = "K. Marder and G. Logroscino and Tang, {M. X.} and J. Graziano and L. Cote and E. Louis and B. Alfaro and H. Mejia and V. Slavkovich and R. Mayeux",

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AU - Marder, K.

AU - Logroscino, G.

AU - Tang, M. X.

AU - Graziano, J.

AU - Cote, L.

AU - Louis, E.

AU - Alfaro, B.

AU - Mejia, H.

AU - Slavkovich, V.

AU - Mayeux, R.

PY - 1998/4

Y1 - 1998/4

N2 - Six measures of systemic iron metabolism were used to predict mortality among 103 patients with Parkinson's disease and 353 controls followed in a longitudinal study. Adjusting for gender, education, ethnicity, presence of dementia, and extrapyramidal signs, transferrin receptor concentration was strongly associated with mortality in patients with PD but not controls. This increase in serum transferrin receptor concentration before death suggests that the previously observed perturbation in iron metabolism continues throughout the disease course.

AB - Six measures of systemic iron metabolism were used to predict mortality among 103 patients with Parkinson's disease and 353 controls followed in a longitudinal study. Adjusting for gender, education, ethnicity, presence of dementia, and extrapyramidal signs, transferrin receptor concentration was strongly associated with mortality in patients with PD but not controls. This increase in serum transferrin receptor concentration before death suggests that the previously observed perturbation in iron metabolism continues throughout the disease course.

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JF - Neurology

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Systemic iron metabolism and mortality from Parkinson's disease

Abstract

ASJC Scopus subject areas

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