Systemic lupus erythematosus diagnostics in the 'omics' era

Cristina Arriens, Chandra Mohan

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Systemic lupus erythematosus is a complex autoimmune disease affecting multiple organ systems. Currently, diagnosis relies upon meeting at least four out of eleven criteria outlined by the ACR. The scientific community actively pursues discovery of novel diagnostics in the hope of better identifying susceptible individuals in early stages of disease. Comprehensive studies have been conducted at multiple biological levels including: DNA (or genomics), mRNA (or transcriptomics), protein (or proteomics) and metabolites (or metabolomics). The 'omics' platforms allow us to re-examine systemic lupus erythematosus at a greater degree of molecular resolution. More importantly, one is hopeful that these 'omics' platforms may yield newer biomarkers for systemic lupus erythematosus that can help clinicians track the disease course with greater sensitivity and specificity.

Original languageEnglish (US)
Pages (from-to)671-687
Number of pages17
JournalInternational Journal of Clinical Rheumatology
Volume8
Issue number6
DOIs
StatePublished - Dec 2013

Keywords

  • epigenomics
  • genomics
  • metabolomics
  • proteomics
  • systemic lupus erythematosus
  • transcriptomics

ASJC Scopus subject areas

  • Rheumatology

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