Systemic lupus erythematosus in three ethnic groups. XX. Damage as a predictor of further damage

Graciela S. Alarcón, J. M. Roseman, G. McGwin, A. Uribe, H. M. Bastian, B. J. Fessler, B. A. Baethge, A. W. Friedman, J. D. Reveille, S. Toloza, B. S. Agee, M. L. Sanchez, E. Sowell, B. Johnson, K. Ho, C. Ahn, R. Sandoval, J. Charles, L. L. Wang, S. HunnicuttL. M. Vilá, W. Borges, C. Pinilla

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Objective. To examine the predictors of damage in a multiethnic cohort of systemic lupus erythematosus (SLE) patients with a specific focus on damage at baseline. Patients and methods. SLE patients from a multiethnic US (Hispanic, African-American and Caucasian) cohort (LUMINA: Lupus in Minority populations, Nature versus nurture) were included if they had ≥6 months of follow-up in the cohort. Damage was measured with the Systemic Lupus International Collaborating Clinics (SLICC) Damage Index (SDI). The dependent variable was the change in SDI score between study visits. Predictors were from the preceding visit. Variables known to affect damage accrual in SLE were included in the analyses. Results. Three hundred and fifty-two patients (82 Hispanics, 153 African-Americans and 117 Caucasians) representing 1795 patient visits were included. Previous damage was found to be a significant predictor of subsequent damage accrual (P < 0.0001). Other variables predictive of subsequent damage accrual were disease activity (P < 0.0001), older age (P=0.041) and use of corticosteroids (P=0.0048). Conclusions. Once damage occurs in SLE, further damage is expected to occur. This is more likely to be the case if disease activity persists. These data have clinical implications for the management of SLE patients.

Original languageEnglish (US)
Pages (from-to)202-205
Number of pages4
JournalRheumatology
Volume43
Issue number2
DOIs
StatePublished - Feb 2004

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Ethnic Groups
Systemic Lupus Erythematosus
Hispanic Americans
African Americans
Adrenal Cortex Hormones
Population

Keywords

  • Damage
  • Ethnicity
  • Lupus
  • Outcome
  • Predictors

ASJC Scopus subject areas

  • Neuroscience(all)
  • Rheumatology

Cite this

Alarcón, G. S., Roseman, J. M., McGwin, G., Uribe, A., Bastian, H. M., Fessler, B. J., ... Pinilla, C. (2004). Systemic lupus erythematosus in three ethnic groups. XX. Damage as a predictor of further damage. Rheumatology, 43(2), 202-205. https://doi.org/10.1093/rheumatology/keg481

Systemic lupus erythematosus in three ethnic groups. XX. Damage as a predictor of further damage. / Alarcón, Graciela S.; Roseman, J. M.; McGwin, G.; Uribe, A.; Bastian, H. M.; Fessler, B. J.; Baethge, B. A.; Friedman, A. W.; Reveille, J. D.; Toloza, S.; Agee, B. S.; Sanchez, M. L.; Sowell, E.; Johnson, B.; Ho, K.; Ahn, C.; Sandoval, R.; Charles, J.; Wang, L. L.; Hunnicutt, S.; Vilá, L. M.; Borges, W.; Pinilla, C.

In: Rheumatology, Vol. 43, No. 2, 02.2004, p. 202-205.

Research output: Contribution to journalArticle

Alarcón, GS, Roseman, JM, McGwin, G, Uribe, A, Bastian, HM, Fessler, BJ, Baethge, BA, Friedman, AW, Reveille, JD, Toloza, S, Agee, BS, Sanchez, ML, Sowell, E, Johnson, B, Ho, K, Ahn, C, Sandoval, R, Charles, J, Wang, LL, Hunnicutt, S, Vilá, LM, Borges, W & Pinilla, C 2004, 'Systemic lupus erythematosus in three ethnic groups. XX. Damage as a predictor of further damage', Rheumatology, vol. 43, no. 2, pp. 202-205. https://doi.org/10.1093/rheumatology/keg481
Alarcón GS, Roseman JM, McGwin G, Uribe A, Bastian HM, Fessler BJ et al. Systemic lupus erythematosus in three ethnic groups. XX. Damage as a predictor of further damage. Rheumatology. 2004 Feb;43(2):202-205. https://doi.org/10.1093/rheumatology/keg481
Alarcón, Graciela S. ; Roseman, J. M. ; McGwin, G. ; Uribe, A. ; Bastian, H. M. ; Fessler, B. J. ; Baethge, B. A. ; Friedman, A. W. ; Reveille, J. D. ; Toloza, S. ; Agee, B. S. ; Sanchez, M. L. ; Sowell, E. ; Johnson, B. ; Ho, K. ; Ahn, C. ; Sandoval, R. ; Charles, J. ; Wang, L. L. ; Hunnicutt, S. ; Vilá, L. M. ; Borges, W. ; Pinilla, C. / Systemic lupus erythematosus in three ethnic groups. XX. Damage as a predictor of further damage. In: Rheumatology. 2004 ; Vol. 43, No. 2. pp. 202-205.
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AU - Alarcón, Graciela S.

AU - Roseman, J. M.

AU - McGwin, G.

AU - Uribe, A.

AU - Bastian, H. M.

AU - Fessler, B. J.

AU - Baethge, B. A.

AU - Friedman, A. W.

AU - Reveille, J. D.

AU - Toloza, S.

AU - Agee, B. S.

AU - Sanchez, M. L.

AU - Sowell, E.

AU - Johnson, B.

AU - Ho, K.

AU - Ahn, C.

AU - Sandoval, R.

AU - Charles, J.

AU - Wang, L. L.

AU - Hunnicutt, S.

AU - Vilá, L. M.

AU - Borges, W.

AU - Pinilla, C.

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N2 - Objective. To examine the predictors of damage in a multiethnic cohort of systemic lupus erythematosus (SLE) patients with a specific focus on damage at baseline. Patients and methods. SLE patients from a multiethnic US (Hispanic, African-American and Caucasian) cohort (LUMINA: Lupus in Minority populations, Nature versus nurture) were included if they had ≥6 months of follow-up in the cohort. Damage was measured with the Systemic Lupus International Collaborating Clinics (SLICC) Damage Index (SDI). The dependent variable was the change in SDI score between study visits. Predictors were from the preceding visit. Variables known to affect damage accrual in SLE were included in the analyses. Results. Three hundred and fifty-two patients (82 Hispanics, 153 African-Americans and 117 Caucasians) representing 1795 patient visits were included. Previous damage was found to be a significant predictor of subsequent damage accrual (P < 0.0001). Other variables predictive of subsequent damage accrual were disease activity (P < 0.0001), older age (P=0.041) and use of corticosteroids (P=0.0048). Conclusions. Once damage occurs in SLE, further damage is expected to occur. This is more likely to be the case if disease activity persists. These data have clinical implications for the management of SLE patients.

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KW - Lupus

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