Systemic lupus erythematosus - Recent clues from congenic strains

Tamika Henry, Chandra Mohan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Systemic lupus erythematosus is a polycongenic autoimmune disease characterized by the production of antinuclear antibodies that lead to subsequent end organ damage. The study of lupus is complicated by its polycongenic origin, contributions from hormones and the environment, epistasis among susceptibility loci, suppressive modifiers, and the fact that a single susceptibility locus may encompass multiple susceptibility genes. Murine models that develop lupus spontaneously have greatly contributed to our understanding of this disease. In particular, the advent of "congenic strains" has greatly simplified the study of this complex autoimmune disease. Thus, congenic strains bearing NZB/NZW/NZM2410, BXSB, and MRL lupus susceptibility loci are steadily replacing the traditionally studied murine lupus models as the models of choice for research. This review summarizes how researchers have used congenic strains over the past few years to dissect out and reconstruct the individual elements contributing to lupus pathogenesis.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume53
Issue number3
StatePublished - May 2005

Fingerprint

Systemic Lupus Erythematosus
Autoimmune Diseases
Antinuclear Antibodies
Research Personnel
Hormones
Research
Genes

Keywords

  • Autoantibodies
  • Congenic strains
  • Lupus
  • Murine lupus

ASJC Scopus subject areas

  • Immunology

Cite this

Systemic lupus erythematosus - Recent clues from congenic strains. / Henry, Tamika; Mohan, Chandra.

In: Archivum Immunologiae et Therapiae Experimentalis, Vol. 53, No. 3, 05.2005, p. 207-212.

Research output: Contribution to journalArticle

Henry, Tamika ; Mohan, Chandra. / Systemic lupus erythematosus - Recent clues from congenic strains. In: Archivum Immunologiae et Therapiae Experimentalis. 2005 ; Vol. 53, No. 3. pp. 207-212.
@article{33a48b42e5b04ce7b6dc8a965ccca41d,
title = "Systemic lupus erythematosus - Recent clues from congenic strains",
abstract = "Systemic lupus erythematosus is a polycongenic autoimmune disease characterized by the production of antinuclear antibodies that lead to subsequent end organ damage. The study of lupus is complicated by its polycongenic origin, contributions from hormones and the environment, epistasis among susceptibility loci, suppressive modifiers, and the fact that a single susceptibility locus may encompass multiple susceptibility genes. Murine models that develop lupus spontaneously have greatly contributed to our understanding of this disease. In particular, the advent of {"}congenic strains{"} has greatly simplified the study of this complex autoimmune disease. Thus, congenic strains bearing NZB/NZW/NZM2410, BXSB, and MRL lupus susceptibility loci are steadily replacing the traditionally studied murine lupus models as the models of choice for research. This review summarizes how researchers have used congenic strains over the past few years to dissect out and reconstruct the individual elements contributing to lupus pathogenesis.",
keywords = "Autoantibodies, Congenic strains, Lupus, Murine lupus",
author = "Tamika Henry and Chandra Mohan",
year = "2005",
month = "5",
language = "English (US)",
volume = "53",
pages = "207--212",
journal = "Archivum Immunologiae et Therapiae Experimentalis",
issn = "0004-069X",
publisher = "Birkhauser Verlag Basel",
number = "3",

}

TY - JOUR

T1 - Systemic lupus erythematosus - Recent clues from congenic strains

AU - Henry, Tamika

AU - Mohan, Chandra

PY - 2005/5

Y1 - 2005/5

N2 - Systemic lupus erythematosus is a polycongenic autoimmune disease characterized by the production of antinuclear antibodies that lead to subsequent end organ damage. The study of lupus is complicated by its polycongenic origin, contributions from hormones and the environment, epistasis among susceptibility loci, suppressive modifiers, and the fact that a single susceptibility locus may encompass multiple susceptibility genes. Murine models that develop lupus spontaneously have greatly contributed to our understanding of this disease. In particular, the advent of "congenic strains" has greatly simplified the study of this complex autoimmune disease. Thus, congenic strains bearing NZB/NZW/NZM2410, BXSB, and MRL lupus susceptibility loci are steadily replacing the traditionally studied murine lupus models as the models of choice for research. This review summarizes how researchers have used congenic strains over the past few years to dissect out and reconstruct the individual elements contributing to lupus pathogenesis.

AB - Systemic lupus erythematosus is a polycongenic autoimmune disease characterized by the production of antinuclear antibodies that lead to subsequent end organ damage. The study of lupus is complicated by its polycongenic origin, contributions from hormones and the environment, epistasis among susceptibility loci, suppressive modifiers, and the fact that a single susceptibility locus may encompass multiple susceptibility genes. Murine models that develop lupus spontaneously have greatly contributed to our understanding of this disease. In particular, the advent of "congenic strains" has greatly simplified the study of this complex autoimmune disease. Thus, congenic strains bearing NZB/NZW/NZM2410, BXSB, and MRL lupus susceptibility loci are steadily replacing the traditionally studied murine lupus models as the models of choice for research. This review summarizes how researchers have used congenic strains over the past few years to dissect out and reconstruct the individual elements contributing to lupus pathogenesis.

KW - Autoantibodies

KW - Congenic strains

KW - Lupus

KW - Murine lupus

UR - http://www.scopus.com/inward/record.url?scp=23044505917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23044505917&partnerID=8YFLogxK

M3 - Article

VL - 53

SP - 207

EP - 212

JO - Archivum Immunologiae et Therapiae Experimentalis

JF - Archivum Immunologiae et Therapiae Experimentalis

SN - 0004-069X

IS - 3

ER -