Systemic-lupus-erythematosus-related acute pancreatitis: A cohort from South China

Yanlong Yang, Yujin Ye, Liuqin Liang, Tianfu Wu, Zhongping Zhan, Xiuyan Yang, Hanshi Xu

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Acute pancreatitis (AP) is a rare but life-threatening complication of SLE. The current study evaluated the clinical characteristics and risk factors for the mortality of patients with SLE-related AP in a cohort of South China. Methods. Inpatient medical records of SLE-related AP were retrospectively reviewed. Results. 27 out of 4053 SLE patients were diagnosed as SLE-related AP, with an overall prevalence of 0.67, annual incidence of 0.56 and mortality of 37.04. SLE patients with AP presented with higher SLEDAI score (21.70 ± 10.32 versus 16.17 ± 7.51, P = 0.03), more organ systems involvement (5.70 ± 1.56 versus 3.96 ± 1.15, P = 0.001), and higher mortality (37.04 versus 0, P = 0.001), compared to patients without AP. Severe AP (SAP) patients had a significant higher mortality rate compared to mild AP (MAP) (75 versus 21.05, P = 0.014). 16 SLE-related AP patients received intensive GC treatment, 75 of them exhibited favorable prognosis. Conclusion. SLE-related AP is rare but concomitant with high mortality in South Chinese people, especially in those SAP patients. Activity of SLE, multiple-organ systems involvement may attribute to the severity and mortality of AP. Appropriate glucocorticosteroid (GC) treatment leads to better prognosis in majority of SLE patients with AP.

Original languageEnglish (US)
Article number568564
JournalClinical and Developmental Immunology
Volume2012
DOIs
StatePublished - Jul 16 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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