TY - JOUR
T1 - Systems approaches for the study of metabolic cycles in yeast
AU - Laxman, Sunil
AU - Tu, Benjamin P.
N1 - Funding Information:
This work was supported by a Burroughs Wellcome Fund Career Award in Biomedical Sciences , a Welch Foundation Research Grant ( I-1697 ), an American Cancer Society/Simmons Cancer Center Institutional Research Grant ( ACS-IRG-02-196 ), and the UT Southwestern Endowed Scholars Program (B.P.T.).
PY - 2010/12
Y1 - 2010/12
N2 - Over four decades ago, the first oscillations in metabolism in yeast cells were reported. Since then, multiple forms of oscillatory behavior have been observed in yeast grown under a variety of continuous culturing environments. The remarkable synchrony of cells undergoing such oscillations has made them ideal subjects for investigation using systems-based approaches. Herein, we briefly summarize previous work on the characterization of such oscillations using systems approaches, and present the long-period, Yeast Metabolic Cycle as an excellent model system for deciphering the temporal organization of fundamental cellular and metabolic processes at unprecedented resolution.
AB - Over four decades ago, the first oscillations in metabolism in yeast cells were reported. Since then, multiple forms of oscillatory behavior have been observed in yeast grown under a variety of continuous culturing environments. The remarkable synchrony of cells undergoing such oscillations has made them ideal subjects for investigation using systems-based approaches. Herein, we briefly summarize previous work on the characterization of such oscillations using systems approaches, and present the long-period, Yeast Metabolic Cycle as an excellent model system for deciphering the temporal organization of fundamental cellular and metabolic processes at unprecedented resolution.
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U2 - 10.1016/j.gde.2010.09.008
DO - 10.1016/j.gde.2010.09.008
M3 - Review article
C2 - 21051220
AN - SCOPUS:78349311963
SN - 0959-437X
VL - 20
SP - 599
EP - 604
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 6
ER -