Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines

Gerlinde Obermoser; Scott Presnell; Kelly Domico; Hui Xu; Yuanyuan Wang; Esperanza Anguiano; Lu Ann Thompson-Snipes; Rajaram Ranganathan; Brad Zeitner; Anna Bjork; David Anderson; Cate Speake; Emily Ruchaud; Jason Skinner; Laia Alsina; Mamta Sharma; Helene Dutartre; Alma Cepika; Elisabeth Israelsson; Phuong Nguyen; Quynh Anh Nguyen; A. Carson Harrod; Sandra M. Zurawski; Virginia Pascual; Hideki Ueno; Gerald T. Nepom; Charlie Quinn; Derek Blankenship; Karolina Palucka; Jacques Banchereau; Damien Chaussabel

doi:10.1016/j.immuni.2012.12.008

Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines

Gerlinde Obermoser, Scott Presnell, Kelly Domico, Hui Xu, Yuanyuan Wang, Esperanza Anguiano, Lu Ann Thompson-Snipes, Rajaram Ranganathan, Brad Zeitner, Anna Bjork, David Anderson, Cate Speake, Emily Ruchaud, Jason Skinner, Laia Alsina, Mamta Sharma, Helene Dutartre, Alma Cepika, Elisabeth Israelsson, Phuong NguyenQuynh Anh Nguyen, A. Carson Harrod, Sandra M. Zurawski, Virginia Pascual, Hideki Ueno, Gerald T. Nepom, Charlie Quinn, Derek Blankenship, Karolina Palucka, Jacques Banchereau, Damien Chaussabel

Research output: Contribution to journal › Article › peer-review

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Abstract

Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.

Original language	English (US)
Pages (from-to)	831-844
Number of pages	14
Journal	Immunity
Volume	38
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2012.12.008
State	Published - Apr 18 2013
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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Obermoser, G., Presnell, S., Domico, K., Xu, H., Wang, Y., Anguiano, E., Thompson-Snipes, L. A., Ranganathan, R., Zeitner, B., Bjork, A., Anderson, D., Speake, C., Ruchaud, E., Skinner, J., Alsina, L., Sharma, M., Dutartre, H., Cepika, A., Israelsson, E., ... Chaussabel, D. (2013). Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. Immunity, 38(4), 831-844. https://doi.org/10.1016/j.immuni.2012.12.008

Obermoser, G, Presnell, S, Domico, K, Xu, H, Wang, Y, Anguiano, E, Thompson-Snipes, LA, Ranganathan, R, Zeitner, B, Bjork, A, Anderson, D, Speake, C, Ruchaud, E, Skinner, J, Alsina, L, Sharma, M, Dutartre, H, Cepika, A, Israelsson, E, Nguyen, P, Nguyen, QA, Harrod, AC, Zurawski, SM, Pascual, V, Ueno, H, Nepom, GT, Quinn, C, Blankenship, D, Palucka, K, Banchereau, J & Chaussabel, D 2013, 'Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines', Immunity, vol. 38, no. 4, pp. 831-844. https://doi.org/10.1016/j.immuni.2012.12.008

@article{181b034018ee495c9b3ddfa65f79f641,

title = "Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines",

abstract = "Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.",

author = "Gerlinde Obermoser and Scott Presnell and Kelly Domico and Hui Xu and Yuanyuan Wang and Esperanza Anguiano and Thompson-Snipes, {Lu Ann} and Rajaram Ranganathan and Brad Zeitner and Anna Bjork and David Anderson and Cate Speake and Emily Ruchaud and Jason Skinner and Laia Alsina and Mamta Sharma and Helene Dutartre and Alma Cepika and Elisabeth Israelsson and Phuong Nguyen and Nguyen, {Quynh Anh} and Harrod, {A. Carson} and Zurawski, {Sandra M.} and Virginia Pascual and Hideki Ueno and Nepom, {Gerald T.} and Charlie Quinn and Derek Blankenship and Karolina Palucka and Jacques Banchereau and Damien Chaussabel",

note = "Funding Information: We thank our volunteer participants and all of the members of BIIR who assisted in this work. We thank I. Berthier, C. Boudreaux, A. Cobb, M. Hughes, B. Lemoine, I. Munagala, D. Nattamai, and colleagues for providing technical assistance with sample preparation, microarray processing, and flow cytometry. We thank A. Garcia-Sastre and R. Albrecht, Department of Microbiology, Mount Sinai School of Medicine, for advice and performing serological assays. We thank E. De Vol, N. Baldwin, and E. Whalen for advice and support in biostatistics and bioinformatics, G. Hayward for help depositing microarray data, M. Roy and O. Vargas for help with editing the wiki site, C. Samuelsen for organizational support, and R. Coffman for discussion of the manuscript. G.O. was supported by an Erwin Schrodinger Research Grant of the Austrian Science Fund and the Medical Research Fund MFF Tirol. The work of D.C., J.B., and K.P. are supported by the Baylor Health Care System Foundation and the National Institutes of Health (U19 AI08998, U19 AI057234, U01 AI082110, N01-AI-15416, and P01 CA084512). J.B., K.P., and D.C. designed the study; G.O., Y.W., E.A., L.T.-S., R.R., E.R, J.S., L.A., M.S., H.D., P.N., Q.-A.N., and S.M.Z. assisted in experiments; H.U. and V.P. supervised the experiments; A.C.H. recruited volunteers; G.O., H.X., Y.W., E.A., A.C., and D.B. analyzed the data; S.P., K.D., B.Z., A.B., D.A., C.S., E.I., G.T.N., and C.Q. provided bioinformatic tools and support, and G.O, K.P., and D.C prepared the manuscript. ",

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doi = "10.1016/j.immuni.2012.12.008",

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volume = "38",

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T1 - Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines

AU - Obermoser, Gerlinde

AU - Presnell, Scott

AU - Domico, Kelly

AU - Xu, Hui

AU - Wang, Yuanyuan

AU - Anguiano, Esperanza

AU - Thompson-Snipes, Lu Ann

AU - Ranganathan, Rajaram

AU - Zeitner, Brad

AU - Bjork, Anna

AU - Anderson, David

AU - Speake, Cate

AU - Ruchaud, Emily

AU - Skinner, Jason

AU - Alsina, Laia

AU - Sharma, Mamta

AU - Dutartre, Helene

AU - Cepika, Alma

AU - Israelsson, Elisabeth

AU - Nguyen, Phuong

AU - Nguyen, Quynh Anh

AU - Harrod, A. Carson

AU - Zurawski, Sandra M.

AU - Pascual, Virginia

AU - Ueno, Hideki

AU - Nepom, Gerald T.

AU - Quinn, Charlie

AU - Blankenship, Derek

AU - Palucka, Karolina

AU - Banchereau, Jacques

AU - Chaussabel, Damien

N1 - Funding Information: We thank our volunteer participants and all of the members of BIIR who assisted in this work. We thank I. Berthier, C. Boudreaux, A. Cobb, M. Hughes, B. Lemoine, I. Munagala, D. Nattamai, and colleagues for providing technical assistance with sample preparation, microarray processing, and flow cytometry. We thank A. Garcia-Sastre and R. Albrecht, Department of Microbiology, Mount Sinai School of Medicine, for advice and performing serological assays. We thank E. De Vol, N. Baldwin, and E. Whalen for advice and support in biostatistics and bioinformatics, G. Hayward for help depositing microarray data, M. Roy and O. Vargas for help with editing the wiki site, C. Samuelsen for organizational support, and R. Coffman for discussion of the manuscript. G.O. was supported by an Erwin Schrodinger Research Grant of the Austrian Science Fund and the Medical Research Fund MFF Tirol. The work of D.C., J.B., and K.P. are supported by the Baylor Health Care System Foundation and the National Institutes of Health (U19 AI08998, U19 AI057234, U01 AI082110, N01-AI-15416, and P01 CA084512). J.B., K.P., and D.C. designed the study; G.O., Y.W., E.A., L.T.-S., R.R., E.R, J.S., L.A., M.S., H.D., P.N., Q.-A.N., and S.M.Z. assisted in experiments; H.U. and V.P. supervised the experiments; A.C.H. recruited volunteers; G.O., H.X., Y.W., E.A., A.C., and D.B. analyzed the data; S.P., K.D., B.Z., A.B., D.A., C.S., E.I., G.T.N., and C.Q. provided bioinformatic tools and support, and G.O, K.P., and D.C prepared the manuscript.

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N2 - Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.

AB - Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.

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ER -

Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines

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