T cell- and B cell-independent adaptive immunity mediated by natural killer cells

Jacqueline G. O'Leary, Mahmoud Goodarzi, Danielle L. Drayton, Ulrich H. von Andrian

Research output: Contribution to journalArticle

510 Citations (Scopus)

Abstract

It is commonly believed that only T lymphocytes and B lymphocytes expressing recombination-dependent antigen-specific receptors mediate contact hypersensitivity responses to haptens. Here we found that mice devoid of T cells and B cells demonstrated substantial contact hypersensitivity responses to 2,4-dinitrofluorobenzene and oxazolone. Those responses were adaptive in nature, as they persisted for at least 4 weeks and were elicited only by haptens to which mice were previously sensitized. No contact hypersensitivity was induced in mice lacking all lymphocytes, including natural killer cells. Contact hypersensitivity responses were acquired by such mice after adoptive transfer of natural killer cells from sensitized donors. Transferable hapten-specific memory resided in a Ly49C-I+ natural killer subpopulation localized specifically in donor livers. These observations indicate that natural killer cells can mediate long-lived, antigen-specific adaptive recall responses independent of B cells and T cells.

Original languageEnglish (US)
Pages (from-to)507-516
Number of pages10
JournalNature Immunology
Volume7
Issue number5
DOIs
StatePublished - May 1 2006

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Contact Dermatitis
Adaptive Immunity
Natural Killer Cells
Haptens
B-Lymphocytes
T-Lymphocytes
Oxazolone
Dinitrofluorobenzene
Antigen Receptors
Adoptive Transfer
Genetic Recombination
Lymphocytes
Antigens
Liver

ASJC Scopus subject areas

  • Immunology

Cite this

T cell- and B cell-independent adaptive immunity mediated by natural killer cells. / O'Leary, Jacqueline G.; Goodarzi, Mahmoud; Drayton, Danielle L.; von Andrian, Ulrich H.

In: Nature Immunology, Vol. 7, No. 5, 01.05.2006, p. 507-516.

Research output: Contribution to journalArticle

O'Leary, Jacqueline G. ; Goodarzi, Mahmoud ; Drayton, Danielle L. ; von Andrian, Ulrich H. / T cell- and B cell-independent adaptive immunity mediated by natural killer cells. In: Nature Immunology. 2006 ; Vol. 7, No. 5. pp. 507-516.
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