T cell-derived B cell growth (BCGF) and differentiation (BCDF) factors: Suppression of the activity of BCDF(μ) but not BCGF by murine bone marrow cells

J. E. Layton, J. W. Uhr, E. Pure, P. H. Krammer, E. S. Vitetta

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Abstract

We have used a system of polyclonal B cell activation to assess the suppressive effect of BM cells on proliferation and differentiation of B cells. In these studies we found that B cell proliferation induced by either LPS or anti-Ig (± T cell supernatants (SN) containing BDGF) is not affected by the addition of BM cells, whereas IgM antibody secretion induced by SN containing BCDF(μ) is strongly inhibited. These data suggest that BM cells do not inhibit clonal expansion of B cells but rather suppress terminal differentation induced either by a mitogen or by T cell-derived lymphokines.

Original languageEnglish (US)
Pages (from-to)2502-2504
Number of pages3
JournalJournal of Immunology
Volume130
Issue number6
StatePublished - 1983

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Growth Differentiation Factors
Bone Marrow Cells
B-Lymphocytes
T-Lymphocytes
Cell Proliferation
Lymphokines
Mitogens
Immunoglobulin M
Cell Differentiation
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

T cell-derived B cell growth (BCGF) and differentiation (BCDF) factors : Suppression of the activity of BCDF(μ) but not BCGF by murine bone marrow cells. / Layton, J. E.; Uhr, J. W.; Pure, E.; Krammer, P. H.; Vitetta, E. S.

In: Journal of Immunology, Vol. 130, No. 6, 1983, p. 2502-2504.

Research output: Contribution to journalArticle

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AU - Uhr, J. W.

AU - Pure, E.

AU - Krammer, P. H.

AU - Vitetta, E. S.

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