T Cell-Derived lymphotoxin is essential for the anti-herpes simplex virus 1 humoral immune response

Kaiting Yang, Yong Liang, Zhichen Sun, Diyuan Xue, Hairong Xu, Mingzhao Zhu, Yang Xin Fu, Hua Peng

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

B cell-derived lymphotoxin (LT) is required for the development of follicular dendritic cell clusters for the formation of primary and secondary lymphoid follicles, but the role of T cell-derived LT in antibody response has not been well demonstrated. We observed that lymphotoxin -receptor (LTβR) signaling is essential for optimal humoral immune response and protection against an acute herpes simplex virus 1 (HSV-1) infection. Blocking the LTβR pathway caused poor maintenance of germinal center B (GC-B) cells and follicular helper T (Tfh) cells. Using bone marrow chimeric mice and adoptive transplantation, we determined that T cell-derived LT played an indispensable role in the humoral immune response to HSV-1. Upregulation of gamma interferon by the LTβR-Ig blockade impairs the sustainability of Tfh-like cells, leading to an impaired humoral immune response. Our findings have identified a novel role of T cell-derived LT in the humoral immune response against HSV-1 infection.

Original languageEnglish (US)
Article numbere00428-18
JournalJournal of Virology
Volume92
Issue number14
DOIs
StatePublished - Jul 1 2018

Fingerprint

lymphotoxin
Human herpesvirus 1
Lymphotoxin-alpha
Human Herpesvirus 1
Humoral Immunity
humoral immunity
T-lymphocytes
T-Lymphocytes
Virus Diseases
receptors
B-lymphocytes
B-Lymphocytes
Follicular Dendritic Cells
Germinal Center
follicular development
dendritic cells
Helper-Inducer T-Lymphocytes
interferon-gamma
infection
bone marrow

Keywords

  • Follicular helper T
  • HSV-1
  • Humoral immune response
  • LTβR
  • Lymphotoxin

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

T Cell-Derived lymphotoxin is essential for the anti-herpes simplex virus 1 humoral immune response. / Yang, Kaiting; Liang, Yong; Sun, Zhichen; Xue, Diyuan; Xu, Hairong; Zhu, Mingzhao; Fu, Yang Xin; Peng, Hua.

In: Journal of Virology, Vol. 92, No. 14, e00428-18, 01.07.2018.

Research output: Contribution to journalArticle

Yang, Kaiting ; Liang, Yong ; Sun, Zhichen ; Xue, Diyuan ; Xu, Hairong ; Zhu, Mingzhao ; Fu, Yang Xin ; Peng, Hua. / T Cell-Derived lymphotoxin is essential for the anti-herpes simplex virus 1 humoral immune response. In: Journal of Virology. 2018 ; Vol. 92, No. 14.
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