Abstract
B cell-derived lymphotoxin (LT) is required for the development of follicular dendritic cell clusters for the formation of primary and secondary lymphoid follicles, but the role of T cell-derived LT in antibody response has not been well demonstrated. We observed that lymphotoxin -receptor (LTβR) signaling is essential for optimal humoral immune response and protection against an acute herpes simplex virus 1 (HSV-1) infection. Blocking the LTβR pathway caused poor maintenance of germinal center B (GC-B) cells and follicular helper T (Tfh) cells. Using bone marrow chimeric mice and adoptive transplantation, we determined that T cell-derived LT played an indispensable role in the humoral immune response to HSV-1. Upregulation of gamma interferon by the LTβR-Ig blockade impairs the sustainability of Tfh-like cells, leading to an impaired humoral immune response. Our findings have identified a novel role of T cell-derived LT in the humoral immune response against HSV-1 infection.
Original language | English (US) |
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Article number | e00428-18 |
Journal | Journal of virology |
Volume | 92 |
Issue number | 14 |
DOIs | |
State | Published - Jul 1 2018 |
Keywords
- Follicular helper T
- HSV-1
- Humoral immune response
- LTβR
- Lymphotoxin
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology