T Cell-Derived lymphotoxin is essential for the anti-herpes simplex virus 1 humoral immune response

Kaiting Yang, Yong Liang, Zhichen Sun, Diyuan Xue, Hairong Xu, Mingzhao Zhu, Yang Xin Fu, Hua Peng

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

B cell-derived lymphotoxin (LT) is required for the development of follicular dendritic cell clusters for the formation of primary and secondary lymphoid follicles, but the role of T cell-derived LT in antibody response has not been well demonstrated. We observed that lymphotoxin -receptor (LTβR) signaling is essential for optimal humoral immune response and protection against an acute herpes simplex virus 1 (HSV-1) infection. Blocking the LTβR pathway caused poor maintenance of germinal center B (GC-B) cells and follicular helper T (Tfh) cells. Using bone marrow chimeric mice and adoptive transplantation, we determined that T cell-derived LT played an indispensable role in the humoral immune response to HSV-1. Upregulation of gamma interferon by the LTβR-Ig blockade impairs the sustainability of Tfh-like cells, leading to an impaired humoral immune response. Our findings have identified a novel role of T cell-derived LT in the humoral immune response against HSV-1 infection.

Original languageEnglish (US)
Article numbere00428-18
JournalJournal of virology
Volume92
Issue number14
DOIs
StatePublished - Jul 1 2018

Keywords

  • Follicular helper T
  • HSV-1
  • Humoral immune response
  • LTβR
  • Lymphotoxin

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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