T cell-derived lymphotoxin limits Th1 response during HSV-1 infection

Kaiting Yang, Yong Liang, Zhichen Sun, Longchao Liu, Jing Liao, Hairong Xu, Mingzhao Zhu, Yang-Xin Fu, Hua Peng

Research output: Contribution to journalArticle

Abstract

Though lymphotoxin (LT) is highly expressed by type I helper T (Th1) cells, its contribution to CD4+ T cell differentiation during infections and diseases remains a mystery. In HSV-1 infection, we observed that LTβR signaling is required to limit the Th1 response. Using bone marrow chimeric mice, mixed-T-cell chimeric mice, and LTβR in vivo blockades, we unexpectedly observed that LT, especially T cell-derived LT, played an indispensable role in limiting the Th1 response. The LTβR-Ig blockade promoted the Th1 response by increasing infiltration of monocytes and monocyte-derived DCs and up-regulating IL-12 secretion in the lymphoid environment. Our findings identified a novel role for T cell-derived LT in manipulating Th1 differentiation.

Original languageEnglish (US)
Article number17727
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Lymphotoxin-alpha
Human Herpesvirus 1
T-Lymphocytes
Infection
Monocytes
Th1 Cells
Helper-Inducer T-Lymphocytes
Cell Differentiation
Bone Marrow

ASJC Scopus subject areas

  • General

Cite this

Yang, K., Liang, Y., Sun, Z., Liu, L., Liao, J., Xu, H., ... Peng, H. (2018). T cell-derived lymphotoxin limits Th1 response during HSV-1 infection. Scientific Reports, 8(1), [17727]. https://doi.org/10.1038/s41598-018-36012-z

T cell-derived lymphotoxin limits Th1 response during HSV-1 infection. / Yang, Kaiting; Liang, Yong; Sun, Zhichen; Liu, Longchao; Liao, Jing; Xu, Hairong; Zhu, Mingzhao; Fu, Yang-Xin; Peng, Hua.

In: Scientific Reports, Vol. 8, No. 1, 17727, 01.12.2018.

Research output: Contribution to journalArticle

Yang, K, Liang, Y, Sun, Z, Liu, L, Liao, J, Xu, H, Zhu, M, Fu, Y-X & Peng, H 2018, 'T cell-derived lymphotoxin limits Th1 response during HSV-1 infection', Scientific Reports, vol. 8, no. 1, 17727. https://doi.org/10.1038/s41598-018-36012-z
Yang, Kaiting ; Liang, Yong ; Sun, Zhichen ; Liu, Longchao ; Liao, Jing ; Xu, Hairong ; Zhu, Mingzhao ; Fu, Yang-Xin ; Peng, Hua. / T cell-derived lymphotoxin limits Th1 response during HSV-1 infection. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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