T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

Aakanksha Jain, Ran Song, Edward K. Wakeland, Chandrashekhar Pasare

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Innate cytokines are critical drivers of priming and differentiation of naive CD4 T cells, but their functions in memory T cell response are largely undefined. Here we show that IL-1 acts as a licensing signal to permit effector cytokine production by pre-committed Th1 (IFN-γ), Th2 (IL-13, IL-4, and IL-5) and Th17 (IL-17A, IL-17F, and IL-22) lineage cells. This licensing function of IL-1 is conserved across effector CD4 T cells generated by diverse immunological insults. IL-1R signaling stabilizes cytokine transcripts to enable productive and rapid effector functions. We also demonstrate that successful lineage commitment does not translate into productive effector functions in the absence of IL-1R signaling. Acute abrogation of IL-1R signaling in vivo results in reduced IL-17A production by intestinal Th17 cells. These results extend the role of innate cytokines beyond CD4 T cell priming and establish IL-1 as a licensing signal for memory CD4 T cell function.

Original languageEnglish (US)
Article number3185
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

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effectors
T-cells
Licensure
licensing
Cytokines
T-Lymphocytes
Data storage equipment
Interleukin-1
priming
Interleukin-17
Th17 Cells
Interleukin-13
Interleukin-5
cells
Interleukin-4

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells. / Jain, Aakanksha; Song, Ran; Wakeland, Edward K.; Pasare, Chandrashekhar.

In: Nature Communications, Vol. 9, No. 1, 3185, 01.12.2018.

Research output: Contribution to journalArticle

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