T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells

Bozidar Purtic, Lisa A. Pitcher, Nicolai S C Van Oers, Christoph Wülfing

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

During T cell activation, T cell receptors (TCR) cluster at the center of the T cell/antigen-presenting cell interface forming a key component of the immunological synapse. The function of this TCR clustering is still unresolved. A comprehensive search for such a function yielded a very limited and specific result. A micrometer-scale receptor clustering integrated the TCR and CD28 signals required for IL-2 secretion in primary 5C.C7 T cells, a low-affinity/avidity TCR system. 5C.C7 TCR signaling itself was not affected. In addition, central TCR accumulation was not required for any T cell effector function tested in three other TCR transgenic models. Central TCR accumulation thus had a specific role in signaling integration in low-affinity T cells.

Original languageEnglish (US)
Pages (from-to)2904-2909
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number8
DOIs
StatePublished - Feb 22 2005

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Costimulatory and Inhibitory T-Cell Receptors
Immunological Synapses
T-Cell Antigen Receptor
Cluster Analysis
T-Lymphocytes
Viral Tumor Antigens
Antigen-Presenting Cells
Interleukin-2

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells. / Purtic, Bozidar; Pitcher, Lisa A.; Van Oers, Nicolai S C; Wülfing, Christoph.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 8, 22.02.2005, p. 2904-2909.

Research output: Contribution to journalArticle

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