T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells

Bozidar Purtic, Lisa A. Pitcher, Nicolai S C Van Oers, Christoph Wülfing

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

During T cell activation, T cell receptors (TCR) cluster at the center of the T cell/antigen-presenting cell interface forming a key component of the immunological synapse. The function of this TCR clustering is still unresolved. A comprehensive search for such a function yielded a very limited and specific result. A micrometer-scale receptor clustering integrated the TCR and CD28 signals required for IL-2 secretion in primary 5C.C7 T cells, a low-affinity/avidity TCR system. 5C.C7 TCR signaling itself was not affected. In addition, central TCR accumulation was not required for any T cell effector function tested in three other TCR transgenic models. Central TCR accumulation thus had a specific role in signaling integration in low-affinity T cells.

Original languageEnglish (US)
Pages (from-to)2904-2909
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number8
DOIs
StatePublished - Feb 22 2005

ASJC Scopus subject areas

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