Abstract
During T cell activation, T cell receptors (TCR) cluster at the center of the T cell/antigen-presenting cell interface forming a key component of the immunological synapse. The function of this TCR clustering is still unresolved. A comprehensive search for such a function yielded a very limited and specific result. A micrometer-scale receptor clustering integrated the TCR and CD28 signals required for IL-2 secretion in primary 5C.C7 T cells, a low-affinity/avidity TCR system. 5C.C7 TCR signaling itself was not affected. In addition, central TCR accumulation was not required for any T cell effector function tested in three other TCR transgenic models. Central TCR accumulation thus had a specific role in signaling integration in low-affinity T cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2904-2909 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 102 |
| Issue number | 8 |
| DOIs | |
| State | Published - Feb 22 2005 |
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ASJC Scopus subject areas
- Genetics
- General
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T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells. / Purtic, Bozidar; Pitcher, Lisa A.; Van Oers, Nicolai S C; Wülfing, Christoph.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 8, 22.02.2005, p. 2904-2909.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells
AU - Purtic, Bozidar
AU - Pitcher, Lisa A.
AU - Van Oers, Nicolai S C
AU - Wülfing, Christoph
PY - 2005/2/22
Y1 - 2005/2/22
N2 - During T cell activation, T cell receptors (TCR) cluster at the center of the T cell/antigen-presenting cell interface forming a key component of the immunological synapse. The function of this TCR clustering is still unresolved. A comprehensive search for such a function yielded a very limited and specific result. A micrometer-scale receptor clustering integrated the TCR and CD28 signals required for IL-2 secretion in primary 5C.C7 T cells, a low-affinity/avidity TCR system. 5C.C7 TCR signaling itself was not affected. In addition, central TCR accumulation was not required for any T cell effector function tested in three other TCR transgenic models. Central TCR accumulation thus had a specific role in signaling integration in low-affinity T cells.
AB - During T cell activation, T cell receptors (TCR) cluster at the center of the T cell/antigen-presenting cell interface forming a key component of the immunological synapse. The function of this TCR clustering is still unresolved. A comprehensive search for such a function yielded a very limited and specific result. A micrometer-scale receptor clustering integrated the TCR and CD28 signals required for IL-2 secretion in primary 5C.C7 T cells, a low-affinity/avidity TCR system. 5C.C7 TCR signaling itself was not affected. In addition, central TCR accumulation was not required for any T cell effector function tested in three other TCR transgenic models. Central TCR accumulation thus had a specific role in signaling integration in low-affinity T cells.
UR - http://www.scopus.com/inward/record.url?scp=14544307446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14544307446&partnerID=8YFLogxK
U2 - 10.1073/pnas.0406867102
DO - 10.1073/pnas.0406867102
M3 - Article
C2 - 15703298
AN - SCOPUS:14544307446
VL - 102
SP - 2904
EP - 2909
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 8
ER -