T regulatory cells and transplantation tolerance

Vijay S. Gorantla; Stefan Schneeberger; Gerald Brandacher; Robert Sucher; Dong Zhang; W. P.Andrew Lee; Xin Xiao Zheng

doi:10.1016/j.trre.2010.04.002

T regulatory cells and transplantation tolerance

Vijay S. Gorantla, Stefan Schneeberger, Gerald Brandacher, Robert Sucher, Dong Zhang, W. P.Andrew Lee, Xin Xiao Zheng

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the "Holy Grail" of transplantation.The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.

Original language	English (US)
Pages (from-to)	147-159
Number of pages	13
Journal	Transplantation Reviews
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.trre.2010.04.002
State	Published - Jul 2010
Externally published	Yes

ASJC Scopus subject areas

Transplantation

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10.1016/j.trre.2010.04.002

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title = "T regulatory cells and transplantation tolerance",

abstract = "Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the {"}Holy Grail{"} of transplantation.The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.",

author = "Gorantla, {Vijay S.} and Stefan Schneeberger and Gerald Brandacher and Robert Sucher and Dong Zhang and Lee, {W. P.Andrew} and Zheng, {Xin Xiao}",

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AU - Gorantla, Vijay S.

AU - Schneeberger, Stefan

AU - Brandacher, Gerald

AU - Sucher, Robert

AU - Zhang, Dong

AU - Lee, W. P.Andrew

AU - Zheng, Xin Xiao

PY - 2010/7

Y1 - 2010/7

N2 - Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the "Holy Grail" of transplantation.The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.

AB - Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the "Holy Grail" of transplantation.The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.

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JO - Transplantation Reviews

JF - Transplantation Reviews

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T regulatory cells and transplantation tolerance

Abstract

ASJC Scopus subject areas

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