T 2 measurement of J-coupled metabolites in the human brain at 3T

Sandeep K. Ganji, Abhishek Banerjee, Aditya M. Patel, Yan D. Zhao, Ivan E. Dimitrov, Jeffrey D. Browning, E. Sherwood Brown, Elizabeth A. Maher, Changho Choi

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Proton T 2 relaxation times of metabolites in the human brain were measured using point resolved spectroscopy at 3T in vivo. Four echo times (54, 112, 246 and 374ms) were selected from numerical and phantom analyses for effective detection of the glutamate multiplet at~2.35ppm. In vivo data were obtained from medial and left occipital cortices of five healthy volunteers. The cortices contained predominantly gray and white matter, respectively. Spectra were analyzed with LCModel software using volume-localized calculated spectra of brain metabolites. The estimate of the signal strength vs. TE was fitted to a monoexponential function for estimation of apparent T 2 (T 2 ). T 2 was estimated to be similar between the brain regions for creatine, choline, glutamate and myo-inositol, but significantly different for N-acetylaspartate singlet and multiplet. T 2 s of glutamate and myo-inositol were measured as 181±16 and 197±14ms (mean±SD, N=5) for medial occipital cortices, and 180±12 and 196±17ms for left occipital cortices, respectively.

Original languageEnglish (US)
Pages (from-to)523-529
Number of pages7
JournalNMR in biomedicine
Volume25
Issue number4
DOIs
StatePublished - Apr 1 2012

    Fingerprint

Keywords

  • 3T
  • Gray matter
  • H-MRS
  • Human brain
  • J-coupled metabolites
  • Relaxation time (T )
  • White matter

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

Cite this