Tailoring to RB: Tumour suppressor status and therapeutic response

Erik S. Knudsen, Karen E. Knudsen

Research output: Contribution to journalReview article

235 Scopus citations

Abstract

The retinoblastoma tumour suppressor (RB) is a crucial regulator of cell-cycle progression that is invoked in response to a myriad of anti-mitogenic signals. It has been hypothesized that perturbations of the RB pathway confer a synonymous proliferative advantage to tumour cells; however, recent findings demonstrate context-specific outcomes associated with such lesions. Particularly, loss of RB function is associated with differential response to wide-ranging therapeutic agents. Thus, the status of this tumour suppressor may be particularly informative in directing treatment regimens.

Original languageEnglish (US)
Pages (from-to)714-724
Number of pages11
JournalNature Reviews Cancer
Volume8
Issue number9
DOIs
StatePublished - Sep 1 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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