TallyHO obese female mice experience poor reproductive outcomes and abnormal blastocyst metabolism that is reversed by metformin

Agriculture & Biology

• metformin 100%
• AMP-activated protein kinase 88%
• blastocyst 61%
• insulin resistance 49%
• metabolism 37%
• mice 37%
• obesity 33%
• tumor necrosis factors 32%
• morula 27%
• embryo (animal) 22%
• pregnancy outcome 22%
• adiponectin 22%
• digoxigenin 20%
• fluids 17%
• lipids 17%
• transferases 16%
• apoptosis 14%
• animal models 14%
• insulin 14%
• phosphorylation 14%
• adverse effects 13%
• deoxyglucose 12%
• 3-hydroxyacyl-CoA dehydrogenase 12%
• uptake mechanisms 10%
• genetic models 9%
• confocal microscopy 8%
• beta oxidation 8%
• litter size 8%
• droplets 7%
• microscopy 7%
• free fatty acids 7%
• dyes 6%
• therapeutics 6%
• pregnancy 5%
• phenotype 5%
• glucose 4%
• assays 4%
• diet 4%
• proteins 2%

Medicine & Life Sciences

• Obese Mice 78%
• AMP-Activated Protein Kinases 76%
• Blastocyst 73%
• Metformin 68%
• Morula 35%
• Embryonic Structures 26%
• Insulin Resistance 26%
• 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene 25%
• Obesity 22%
• Digoxigenin 22%
• Adiponectin 17%
• Tumor Necrosis Factor-alpha 17%
• Insulin 16%
• Pregnancy Outcome 16%
• Lipids 15%
• Confocal Microscopy 15%
• Enoyl-CoA Hydratase 13%
• Fatty Acids 13%
• Acetyl-CoA C-Acyltransferase 13%
• Litter Size 11%
• Phosphorylation 11%
• Coenzyme A 10%
• Apoptosis 9%
• Lipid Droplets 9%
• DNA Nucleotidylexotransferase 9%
• Deoxyglucose 9%
• Protein Subunits 9%
• Genetic Models 8%
• Transferases 8%
• Inbred C57BL Mouse 7%
• Infertility 7%
• Oxidoreductases 7%
• Coloring Agents 6%
• Diet 5%
• Western Blotting 5%
• Weights and Measures 5%
• Glucose 5%
• Pregnancy 4%
• Phenotype 4%
• In Vitro Techniques 3%
• Therapeutics 1%