Tango7 directs cellular remodeling by the Drosophila apoptosome

Alejandro D'Brot, Po Chen, Mahesh Vaishnav, Shujun Yuan, Christopher W. Akey, John M. Abrams

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Drosophila apoptosome to drive a caspase-dependent remodeling process needed to resolve individual sperm from a syncytium. In these cells, Tango7 is required for caspase activity and localizes to the active apoptosome compartment via its C terminus. Furthermore, Tango7 directly stimulates the activity of this complex in vitro. We propose that Tango7 specifies the Drosophila apoptosome as an effector of cellular remodeling.

Original languageEnglish (US)
Pages (from-to)1650-1655
Number of pages6
JournalGenes and Development
Volume27
Issue number15
DOIs
StatePublished - Aug 1 2013

Keywords

  • Apoptosis
  • Apoptosome
  • Caspase activity
  • Cell death
  • Cellular remodeling

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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