Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats

Xi Yong Yu, Shu Guang Lin, Zhi Wei Zhou, Xiao Chen, Jun Liang, Wei Duan, Xue Qing Yu, Jing Yuan Wen, Balram Chowbay, Chun Guang Li, Fwu Shan Sheu, Eli Chan, Shu Feng Zhou

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Tanshinone IIB (TSB) is a major active constituent of the root of Salvia miltiorrhiza (Danshen) used in the treatment of acute stroke. Danshen extracts and TSB have shown marked neuron-protective effects in mouse studies but there is a lack of clinical evidence for the neuron-protective effects of Danshen and its active ingredients. This study investigated the neuron-protective effects of TSB in experimentally stroked rats. TSB at 5 and 25 mg/kg by intraperitoneal injection significantly reduced the focal infarct volume, cerebral histological damage and apoptosis in rats subjected to middle cerebral artery occlusion (MCAO) compared to MCAO rats receiving vehicle. This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalNeuroscience letters
Volume417
Issue number3
DOIs
StatePublished - May 7 2007
Externally publishedYes

Keywords

  • Focal infarct
  • Middle cerebral artery occlusion
  • Rat
  • Stroke
  • Tanshinone IIB

ASJC Scopus subject areas

  • Neuroscience(all)

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