Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats

Xi Yong Yu; Shu Guang Lin; Zhi Wei Zhou; Xiao Chen; Jun Liang; Wei Duan; Xue Qing Yu; Jing Yuan Wen; Balram Chowbay; Chun Guang Li; Fwu Shan Sheu; Eli Chan; Shu Feng Zhou

doi:10.1016/j.neulet.2007.02.079

Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats

Xi Yong Yu, Shu Guang Lin, Zhi Wei Zhou, Xiao Chen, Jun Liang, Wei Duan, Xue Qing Yu, Jing Yuan Wen, Balram Chowbay, Chun Guang Li, Fwu Shan Sheu, Eli Chan, Shu Feng Zhou

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Tanshinone IIB (TSB) is a major active constituent of the root of Salvia miltiorrhiza (Danshen) used in the treatment of acute stroke. Danshen extracts and TSB have shown marked neuron-protective effects in mouse studies but there is a lack of clinical evidence for the neuron-protective effects of Danshen and its active ingredients. This study investigated the neuron-protective effects of TSB in experimentally stroked rats. TSB at 5 and 25 mg/kg by intraperitoneal injection significantly reduced the focal infarct volume, cerebral histological damage and apoptosis in rats subjected to middle cerebral artery occlusion (MCAO) compared to MCAO rats receiving vehicle. This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB.

Original language	English (US)
Pages (from-to)	261-265
Number of pages	5
Journal	Neuroscience letters
Volume	417
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2007.02.079
State	Published - May 7 2007
Externally published	Yes

Keywords

Focal infarct
Middle cerebral artery occlusion
Rat
Stroke
Tanshinone IIB

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2007.02.079

Cite this

Yu, X. Y., Lin, S. G., Zhou, Z. W., Chen, X., Liang, J., Duan, W., Yu, X. Q., Wen, J. Y., Chowbay, B., Li, C. G., Sheu, F. S., Chan, E., & Zhou, S. F. (2007). Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats. Neuroscience letters, 417(3), 261-265. https://doi.org/10.1016/j.neulet.2007.02.079

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title = "Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats",

abstract = "Tanshinone IIB (TSB) is a major active constituent of the root of Salvia miltiorrhiza (Danshen) used in the treatment of acute stroke. Danshen extracts and TSB have shown marked neuron-protective effects in mouse studies but there is a lack of clinical evidence for the neuron-protective effects of Danshen and its active ingredients. This study investigated the neuron-protective effects of TSB in experimentally stroked rats. TSB at 5 and 25 mg/kg by intraperitoneal injection significantly reduced the focal infarct volume, cerebral histological damage and apoptosis in rats subjected to middle cerebral artery occlusion (MCAO) compared to MCAO rats receiving vehicle. This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB.",

keywords = "Focal infarct, Middle cerebral artery occlusion, Rat, Stroke, Tanshinone IIB",

author = "Yu, {Xi Yong} and Lin, {Shu Guang} and Zhou, {Zhi Wei} and Xiao Chen and Jun Liang and Wei Duan and Yu, {Xue Qing} and Wen, {Jing Yuan} and Balram Chowbay and Li, {Chun Guang} and Sheu, {Fwu Shan} and Eli Chan and Zhou, {Shu Feng}",

note = "Funding Information: The authors appreciate the support provided by Guangdong Provincial Cardiovascular Institute (Guangzhou, China), National 973 Grand Project of China (No. 2005CB523305), Australian Institute of Chinese Medicine, Sydney, Australia (Grant No. R-106-00341), Singapore Cancer Syndicate Grant SCS PS0023, and the Queensland University of Technology (Brisbane, Queensland, Australia). ",

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doi = "10.1016/j.neulet.2007.02.079",

language = "English (US)",

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issn = "0304-3940",

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T1 - Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats

AU - Yu, Xi Yong

AU - Lin, Shu Guang

AU - Zhou, Zhi Wei

AU - Chen, Xiao

AU - Liang, Jun

AU - Duan, Wei

AU - Yu, Xue Qing

AU - Wen, Jing Yuan

AU - Chowbay, Balram

AU - Li, Chun Guang

AU - Sheu, Fwu Shan

AU - Chan, Eli

AU - Zhou, Shu Feng

N1 - Funding Information: The authors appreciate the support provided by Guangdong Provincial Cardiovascular Institute (Guangzhou, China), National 973 Grand Project of China (No. 2005CB523305), Australian Institute of Chinese Medicine, Sydney, Australia (Grant No. R-106-00341), Singapore Cancer Syndicate Grant SCS PS0023, and the Queensland University of Technology (Brisbane, Queensland, Australia).

PY - 2007/5/7

Y1 - 2007/5/7

N2 - Tanshinone IIB (TSB) is a major active constituent of the root of Salvia miltiorrhiza (Danshen) used in the treatment of acute stroke. Danshen extracts and TSB have shown marked neuron-protective effects in mouse studies but there is a lack of clinical evidence for the neuron-protective effects of Danshen and its active ingredients. This study investigated the neuron-protective effects of TSB in experimentally stroked rats. TSB at 5 and 25 mg/kg by intraperitoneal injection significantly reduced the focal infarct volume, cerebral histological damage and apoptosis in rats subjected to middle cerebral artery occlusion (MCAO) compared to MCAO rats receiving vehicle. This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB.

AB - Tanshinone IIB (TSB) is a major active constituent of the root of Salvia miltiorrhiza (Danshen) used in the treatment of acute stroke. Danshen extracts and TSB have shown marked neuron-protective effects in mouse studies but there is a lack of clinical evidence for the neuron-protective effects of Danshen and its active ingredients. This study investigated the neuron-protective effects of TSB in experimentally stroked rats. TSB at 5 and 25 mg/kg by intraperitoneal injection significantly reduced the focal infarct volume, cerebral histological damage and apoptosis in rats subjected to middle cerebral artery occlusion (MCAO) compared to MCAO rats receiving vehicle. This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB.

KW - Focal infarct

KW - Middle cerebral artery occlusion

KW - Rat

KW - Stroke

KW - Tanshinone IIB

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Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats

Abstract

Keywords

ASJC Scopus subject areas

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