Targeted MAPK pathway inhibitors in patients with disseminated pilocytic astrocytomas

Anastasia Drobysheva, Laura J Klesse, Daniel C Bowers, Veena Rajaram, Dinesh Rakheja, Charles F Timmons, Jason Wang, Korgun Koral, Lynn Gargan, Erica Ramos, Jason Y Park

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

This report presents a series of 5 pediatric patients with disseminated pilocytic astrocytomas and frequent nonfusion activating mutations. Genetic variants in these patients' tumors include BRAF p.Val600Glu, BRAF p.Val600Asp, and KRAS p.Gly60-Gln62ins7. The 2 patients with BRAF-mutated tumors were treated with dabrafenib or a combination of dabrafenib plus trametinib. The patients had either near complete resolution of the primary tumor (BRAF p.Val600Glu) or a stable primary tumor (BRAF p.Val600Asp). Both patients showed improvement in leptomeningeal dissemination without significant toxicity. Genomic testing of disseminated pilocytic astrocytomas, particularly those arising at extracerebellar locations, may result in the identification of mutations associated with ERK/MAPK activation. Patients with these activating mutations may benefit from targeted therapies.

Original languageEnglish (US)
Pages (from-to)978-982
Number of pages5
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume15
Issue number8
DOIs
StatePublished - Aug 1 2017

ASJC Scopus subject areas

  • Oncology

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