Targeted molecular ultrasound therapy improves chemotherapeutic drug delivery in cancer cells

Anna G. Sorace, Reshu Saini, Marshall J. Mahoney, Kenneth Hoyt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microbubble (MB) mediated ultrasound (US) therapy has been shown to non-invasively increase drug uptake through increasing cell membrane permeability and vascular extravasation. Increasing MB-cell interaction through targeted receptors overexpressed in the tumor vasculature promises to increase effectiveness of MB-mediated US therapy. 2LMP breast cancer cells were plated on acoustically transparent tissue culture plates. Using a model system which allows receptor density modulation, molecular US therapy was analyzed for anticancer effects in vitro. Drug (paclitaxel) effectiveness in combination with traditional MB-mediated US therapy or molecular US therapy was analyzed using flow cytometry and ATPlite assays. It was shown that molecular US therapy significantly increases anticancer effects by 25% compared to traditional MB-mediated US therapy (P < 0.001). This preclinical approach has potential to increase localized delivery through a targeted methodology, thereby potentially decreasing systemically toxicity. This study demonstrates that MBs targeted to cellular receptors are a promising addition to MB-mediated US therapy.

Original languageEnglish (US)
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages429-432
Number of pages4
DOIs
Publication statusPublished - Dec 1 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

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ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Sorace, A. G., Saini, R., Mahoney, M. J., & Hoyt, K. (2012). Targeted molecular ultrasound therapy improves chemotherapeutic drug delivery in cancer cells. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 429-432). [6562479] https://doi.org/10.1109/ULTSYM.2012.0106