Targeted molecular ultrasound therapy improves chemotherapeutic drug delivery in cancer cells

Anna G. Sorace, Reshu Saini, Marshall J. Mahoney, Kenneth Hoyt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microbubble (MB) mediated ultrasound (US) therapy has been shown to non-invasively increase drug uptake through increasing cell membrane permeability and vascular extravasation. Increasing MB-cell interaction through targeted receptors overexpressed in the tumor vasculature promises to increase effectiveness of MB-mediated US therapy. 2LMP breast cancer cells were plated on acoustically transparent tissue culture plates. Using a model system which allows receptor density modulation, molecular US therapy was analyzed for anticancer effects in vitro. Drug (paclitaxel) effectiveness in combination with traditional MB-mediated US therapy or molecular US therapy was analyzed using flow cytometry and ATPlite assays. It was shown that molecular US therapy significantly increases anticancer effects by 25% compared to traditional MB-mediated US therapy (P < 0.001). This preclinical approach has potential to increase localized delivery through a targeted methodology, thereby potentially decreasing systemically toxicity. This study demonstrates that MBs targeted to cellular receptors are a promising addition to MB-mediated US therapy.

Original languageEnglish (US)
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages429-432
Number of pages4
DOIs
StatePublished - Dec 1 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

Fingerprint

therapy
delivery
drugs
cancer
cytometry
breast
toxicity
permeability
tumors
methodology
modulation
cells
interactions

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Sorace, A. G., Saini, R., Mahoney, M. J., & Hoyt, K. (2012). Targeted molecular ultrasound therapy improves chemotherapeutic drug delivery in cancer cells. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 429-432). [6562479] https://doi.org/10.1109/ULTSYM.2012.0106

Targeted molecular ultrasound therapy improves chemotherapeutic drug delivery in cancer cells. / Sorace, Anna G.; Saini, Reshu; Mahoney, Marshall J.; Hoyt, Kenneth.

2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 429-432 6562479.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sorace, AG, Saini, R, Mahoney, MJ & Hoyt, K 2012, Targeted molecular ultrasound therapy improves chemotherapeutic drug delivery in cancer cells. in 2012 IEEE International Ultrasonics Symposium, IUS 2012., 6562479, pp. 429-432, 2012 IEEE International Ultrasonics Symposium, IUS 2012, Dresden, Germany, 10/7/12. https://doi.org/10.1109/ULTSYM.2012.0106
Sorace AG, Saini R, Mahoney MJ, Hoyt K. Targeted molecular ultrasound therapy improves chemotherapeutic drug delivery in cancer cells. In 2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 429-432. 6562479 https://doi.org/10.1109/ULTSYM.2012.0106
Sorace, Anna G. ; Saini, Reshu ; Mahoney, Marshall J. ; Hoyt, Kenneth. / Targeted molecular ultrasound therapy improves chemotherapeutic drug delivery in cancer cells. 2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. pp. 429-432
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