Targeted temperature management for cardiac arrest

Research output: Contribution to journalReview article

Abstract

Therapeutic hypothermia, or targeted temperature management (TTM), is a strategy of reducing the core body temperature of survivors of sudden cardiac arrest (SCA) to minimize neurological damage caused by severe hypoxia. Initial clinical trials examining this technique demonstrated significant improvement in neurological function among survivors of out-of-hospital SCA with an initial shockable rhythm. Since then, TTM has become an integral part of the care provided to comatose survivors of SCA. However, multiple questions persist regarding the target cooling temperature, duration of cooling, and utility of TTM in patient populations such as survivors of out-of-hospital SCA with non-shockable rhythms or in-hospital SCA. This review article summarizes the current evidence regarding optimal application of TTM and compares the recommendations for TTM in current guidelines.

Original languageEnglish (US)
JournalProgress in Cardiovascular Diseases
DOIs
StatePublished - Jan 1 2019

Fingerprint

Heart Arrest
Sudden Cardiac Death
Temperature
Survivors
Out-of-Hospital Cardiac Arrest
Induced Hypothermia
Coma
Body Temperature
Clinical Trials
Guidelines
Population

Keywords

  • Cardiac arrest
  • Hypothermia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Targeted temperature management for cardiac arrest. / Mody, Purav; Kulkarni, Nitin; Khera, Rohan; Link, Mark S.

In: Progress in Cardiovascular Diseases, 01.01.2019.

Research output: Contribution to journalReview article

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