Targeted therapies for stage III non-small cell lung cancer: Integration in the combined modality setting

Everett E. Vokes, Hak Choy

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Combined modality therapy represents current standard therapy for locoregionally advanced non-small cell lung cancer. In particular, concomitant chemoradiotherapy has emerged as the preferred approach. At the same time, efforts to increase locoregional and systemic antitumor activity are necessary to further improve long-term survival rates for these patients. In recent years, multiple cellular targets have emerged in the development of novel antitumor therapies. Several of these are of high relevance in the carcinogenesis of lung cancer including the epidermal growth factor receptor (EGFR), the ras signaling pathway, tumor angiogenesis, and cyclooxygenase-2 (COX-2) expression. Novel agents directed against these targets are currently under development with promising early results in non-small cell lung cancer when administered as single agents or in combination with chemotherapy in stage IV or recurrent disease. Similarly their use with concurrent radiation therapy is supported by preclinical models. Selected early clinical trials utilizing these agents in combination with radiotherapy or chemoradiotherapy are discussed.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalLung Cancer
Volume41
Issue numberSUPPL. 1
DOIs
StatePublished - Aug 1 2003

    Fingerprint

Keywords

  • Non-small cell lung cancer
  • Preclinical models
  • Stage III

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this