Targeting adipose tissue in the treatment of obesity-associated diabetes

Research output: Contribution to journalArticle

206 Scopus citations

Abstract

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. In this Review, we provide an overview of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic strategies targeting adipose tissue, including adipokine-based strategies, promotion of white adipose tissue beiging as well as reduction of inflammation and fibrosis.

Original languageEnglish (US)
JournalNature Reviews Drug Discovery
DOIs
StateAccepted/In press - Jun 3 2016

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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