Targeting breast cancer metastasis

Xin Jin; Ping Mu

doi:10.4137/BCBCR.S25460

Targeting breast cancer metastasis

Xin Jin, Ping Mu

Research output: Contribution to journal › Article › peer-review

169 Scopus citations

Abstract

Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 30-40% of patients may eventually suffer from distant relapse and succumb to the disease. Consequently, a deeper understanding of the metastasis biology is key to developing better treatment strategies and achieving long-lasting therapeutic efficacies against breast cancer. This review covers recent breakthroughs in the discovery of various metastatic traits that contribute to the metastasis cascade of breast cancer, which may provide novel avenues for therapeutic targeting.

Original language	English (US)
Pages (from-to)	23-34
Number of pages	12
Journal	Breast Cancer: Basic and Clinical Research
Volume	9
DOIs	https://doi.org/10.4137/BCBCR.S25460
State	Published - Sep 2 2015
Externally published	Yes

Keywords

Breast cancer
Metastasis
Metastatic traits
Precision medicine
Targeted therapy

ASJC Scopus subject areas

Oncology
Cancer Research

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10.4137/BCBCR.S25460

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abstract = "Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 30-40% of patients may eventually suffer from distant relapse and succumb to the disease. Consequently, a deeper understanding of the metastasis biology is key to developing better treatment strategies and achieving long-lasting therapeutic efficacies against breast cancer. This review covers recent breakthroughs in the discovery of various metastatic traits that contribute to the metastasis cascade of breast cancer, which may provide novel avenues for therapeutic targeting.",

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AU - Mu, Ping

N1 - Publisher Copyright: © the authors, publisher and licensee Libertas Academica Limited.

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Y1 - 2015/9/2

N2 - Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 30-40% of patients may eventually suffer from distant relapse and succumb to the disease. Consequently, a deeper understanding of the metastasis biology is key to developing better treatment strategies and achieving long-lasting therapeutic efficacies against breast cancer. This review covers recent breakthroughs in the discovery of various metastatic traits that contribute to the metastasis cascade of breast cancer, which may provide novel avenues for therapeutic targeting.

AB - Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 30-40% of patients may eventually suffer from distant relapse and succumb to the disease. Consequently, a deeper understanding of the metastasis biology is key to developing better treatment strategies and achieving long-lasting therapeutic efficacies against breast cancer. This review covers recent breakthroughs in the discovery of various metastatic traits that contribute to the metastasis cascade of breast cancer, which may provide novel avenues for therapeutic targeting.

KW - Breast cancer

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KW - Metastatic traits

KW - Precision medicine

KW - Targeted therapy

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ER -

Targeting breast cancer metastasis

Abstract

Keywords

ASJC Scopus subject areas

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