TY - JOUR
T1 - Targeting cancer's metabolic co-dependencies
T2 - A landscape shaped by genotype and tissue context
AU - Bi, Junfeng
AU - Wu, Sihan
AU - Zhang, Wenjing
AU - Mischel, Paul S.
N1 - Funding Information:
This work was supported by the Ludwig Institute for Cancer Research (100011) and grants from National Institute for Neurological Diseases and Stroke (NS73831), the Defeat GBM Program of the National Brain Tumor Society, the Ben and Catherine Ivy Foundation, an award from the Sharpe/National Brain Tumor Society Research Program, and a generous donations from the Ziering Family Foundation in memory of Sigi Ziering (P.S.M.). We regret that due to space limitations, we have not been able to include many important studies that have shaped, and continue to shape our understanding of cancer metabolism.
Funding Information:
This work was supported by the Ludwig Institute for Cancer Research ( 100011 ) and grants from National Institute for Neurological Diseases and Stroke ( NS73831 ), the Defeat GBM Program of the National Brain Tumor Society , the Ben and Catherine Ivy Foundation , an award from the Sharpe/National Brain Tumor Society Research Program, and a generous donations from the Ziering Family Foundation in memory of Sigi Ziering (P.S.M.). We regret that due to space limitations, we have not been able to include many important studies that have shaped, and continue to shape our understanding of cancer metabolism.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/8
Y1 - 2018/8
N2 - Tumors cells reprogram their metabolism to fuel rapid growth. The ability to trace nutrient fluxes in the context of specific alterations has provided new mechanistic insight into the process of oncogenic transformation. A broad array of complementary genetic, epigenetic, transcriptional and translational mechanisms has been identified, revealing a metabolic landscape of cancer. However, cancer metabolism is not a static or uniform process, including within a single tumor. Tumor cells adapt to changing environmental conditions, profoundly shaping the enzymatic dependencies of individual cells. The underlying molecular mechanisms of adaptation, and the specific interactions between tumor genotype, oncogenic signaling, and tissue/biochemical context, remain incompletely understood. In this review, we examine dynamic aspects of how metabolic dependencies develop in cancer, shaped both by genotype and biochemical environment, and review how these interlaced processes generate targetable metabolic vulnerabilities. This article is part of a Special Issue entitled: Cancer Metabolism edited by Dr. Chi Van Dang.
AB - Tumors cells reprogram their metabolism to fuel rapid growth. The ability to trace nutrient fluxes in the context of specific alterations has provided new mechanistic insight into the process of oncogenic transformation. A broad array of complementary genetic, epigenetic, transcriptional and translational mechanisms has been identified, revealing a metabolic landscape of cancer. However, cancer metabolism is not a static or uniform process, including within a single tumor. Tumor cells adapt to changing environmental conditions, profoundly shaping the enzymatic dependencies of individual cells. The underlying molecular mechanisms of adaptation, and the specific interactions between tumor genotype, oncogenic signaling, and tissue/biochemical context, remain incompletely understood. In this review, we examine dynamic aspects of how metabolic dependencies develop in cancer, shaped both by genotype and biochemical environment, and review how these interlaced processes generate targetable metabolic vulnerabilities. This article is part of a Special Issue entitled: Cancer Metabolism edited by Dr. Chi Van Dang.
KW - Cancer metabolism
KW - Heterogeneity
KW - Metabolic co-dependency
KW - Oncogenic signaling
KW - Tissue context
KW - ecDNA
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U2 - 10.1016/j.bbcan.2018.05.002
DO - 10.1016/j.bbcan.2018.05.002
M3 - Review article
C2 - 29775654
AN - SCOPUS:85047330350
SN - 0304-419X
VL - 1870
SP - 76
EP - 87
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 1
ER -