Targeting ferroptosis in pancreatic cancer: a double-edged sword

Xin Chen, Rui Kang, Guido Kroemer, Daolin Tang

Research output: Contribution to journalReview articlepeer-review

Abstract

Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive malignancy with a 5-year survival rate below 10%. Its unique genetic makeup and tumor microenvironment produce a lack of response to current treatments, including chemotherapy, radiotherapy, and immunotherapy. Recent preclinical studies have revealed that ferroptosis, an iron-dependent form of nonapoptotic cell death driven by unrestricted lipid peroxidation, may be an attractive therapeutic goal in PDAC. Understanding the dual role of ferroptotic cell death in both promoting and suppressing tumor immunity, as well as its integrated regulatory mechanisms and signaling pathways, may lead to more effective treatment designs for clinical trials of PDAC and may minimize or delay the emergence of drug resistance or side effects.

Original languageEnglish (US)
JournalTrends in Cancer
DOIs
StateAccepted/In press - 2021

Keywords

  • cell death
  • ferroptosis
  • pancreatic cancer
  • redox signaling
  • therapy resistance
  • tumor microenvironment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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