Targeting ferroptosis in pancreatic cancer: a double-edged sword

Xin Chen; Rui Kang; Guido Kroemer; Daolin Tang

doi:10.1016/j.trecan.2021.04.005

Targeting ferroptosis in pancreatic cancer: a double-edged sword

Xin Chen, Rui Kang, Guido Kroemer, Daolin Tang

Research output: Contribution to journal › Review article › peer-review

76 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive malignancy with a 5-year survival rate below 10%. Its unique genetic makeup and tumor microenvironment produce a lack of response to current treatments, including chemotherapy, radiotherapy, and immunotherapy. Recent preclinical studies have revealed that ferroptosis, an iron-dependent form of nonapoptotic cell death driven by unrestricted lipid peroxidation, may be an attractive therapeutic goal in PDAC. Understanding the dual role of ferroptotic cell death in both promoting and suppressing tumor immunity, as well as its integrated regulatory mechanisms and signaling pathways, may lead to more effective treatment designs for clinical trials of PDAC and may minimize or delay the emergence of drug resistance or side effects.

Original language	English (US)
Pages (from-to)	891-901
Number of pages	11
Journal	Trends in Cancer
Volume	7
Issue number	10
DOIs	https://doi.org/10.1016/j.trecan.2021.04.005
State	Published - Oct 2021

Keywords

cell death
ferroptosis
pancreatic cancer
redox signaling
therapy resistance
tumor microenvironment

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2021.04.005

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title = "Targeting ferroptosis in pancreatic cancer: a double-edged sword",

abstract = "Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive malignancy with a 5-year survival rate below 10%. Its unique genetic makeup and tumor microenvironment produce a lack of response to current treatments, including chemotherapy, radiotherapy, and immunotherapy. Recent preclinical studies have revealed that ferroptosis, an iron-dependent form of nonapoptotic cell death driven by unrestricted lipid peroxidation, may be an attractive therapeutic goal in PDAC. Understanding the dual role of ferroptotic cell death in both promoting and suppressing tumor immunity, as well as its integrated regulatory mechanisms and signaling pathways, may lead to more effective treatment designs for clinical trials of PDAC and may minimize or delay the emergence of drug resistance or side effects.",

keywords = "cell death, ferroptosis, pancreatic cancer, redox signaling, therapy resistance, tumor microenvironment",

author = "Xin Chen and Rui Kang and Guido Kroemer and Daolin Tang",

note = "Funding Information: We thank Dave Primm (Department of Surgery, University of Texas Southwestern Medical Center) for his critical reading of the manuscript. We thank our numerous colleagues who investigate ferroptosis. We also apologize to the researchers who were not referenced due to space limitations. X.C. and D.T. wrote the manuscript. G.K. and R.K. edited the manuscript. All authors approved the submitted version. The authors have no interests to declare. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

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doi = "10.1016/j.trecan.2021.04.005",

language = "English (US)",

volume = "7",

pages = "891--901",

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T1 - Targeting ferroptosis in pancreatic cancer

T2 - a double-edged sword

AU - Chen, Xin

AU - Kang, Rui

AU - Kroemer, Guido

AU - Tang, Daolin

N1 - Funding Information: We thank Dave Primm (Department of Surgery, University of Texas Southwestern Medical Center) for his critical reading of the manuscript. We thank our numerous colleagues who investigate ferroptosis. We also apologize to the researchers who were not referenced due to space limitations. X.C. and D.T. wrote the manuscript. G.K. and R.K. edited the manuscript. All authors approved the submitted version. The authors have no interests to declare. Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021/10

Y1 - 2021/10

N2 - Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive malignancy with a 5-year survival rate below 10%. Its unique genetic makeup and tumor microenvironment produce a lack of response to current treatments, including chemotherapy, radiotherapy, and immunotherapy. Recent preclinical studies have revealed that ferroptosis, an iron-dependent form of nonapoptotic cell death driven by unrestricted lipid peroxidation, may be an attractive therapeutic goal in PDAC. Understanding the dual role of ferroptotic cell death in both promoting and suppressing tumor immunity, as well as its integrated regulatory mechanisms and signaling pathways, may lead to more effective treatment designs for clinical trials of PDAC and may minimize or delay the emergence of drug resistance or side effects.

AB - Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive malignancy with a 5-year survival rate below 10%. Its unique genetic makeup and tumor microenvironment produce a lack of response to current treatments, including chemotherapy, radiotherapy, and immunotherapy. Recent preclinical studies have revealed that ferroptosis, an iron-dependent form of nonapoptotic cell death driven by unrestricted lipid peroxidation, may be an attractive therapeutic goal in PDAC. Understanding the dual role of ferroptotic cell death in both promoting and suppressing tumor immunity, as well as its integrated regulatory mechanisms and signaling pathways, may lead to more effective treatment designs for clinical trials of PDAC and may minimize or delay the emergence of drug resistance or side effects.

KW - cell death

KW - ferroptosis

KW - pancreatic cancer

KW - redox signaling

KW - therapy resistance

KW - tumor microenvironment

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DO - 10.1016/j.trecan.2021.04.005

M3 - Review article

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AN - SCOPUS:85106377307

SN - 2405-8033

VL - 7

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EP - 901

JO - Trends in Cancer

JF - Trends in Cancer

IS - 10

ER -

Targeting ferroptosis in pancreatic cancer: a double-edged sword

Abstract

Keywords

ASJC Scopus subject areas

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