Targeting hypoxia-mediated mucin 2 production as a therapeutic strategy for mucinous tumors

Medicine & Life Sciences

• Mucin-2 100%
• Pseudomyxoma Peritonei 88%
• 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine 57%
• Hypoxia 45%
• Neoplasms 18%
• Mucins 17%
• Growth 16%
• Heterografts 14%
• Small Interfering RNA 13%
• Proteins 12%
• Hypoxia-Inducible Factor 1 10%
• Cell Hypoxia 10%
• Therapeutics 9%
• Messenger RNA 9%
• Peritoneal Cavity 9%
• Gels 6%
• Down-Regulation 5%
• Morbidity 4%
• Mortality 4%
• In Vitro Techniques 3%

Chemical Compounds

• Small Interfering RNA 40%
• Messenger RNA 38%
• Protein 24%
• Intraperitoneal 18%

Social Sciences

• mortality 12%
• cause 8%
• regulation 8%