Abstract
Vascular targeting is currently being explored as a new therapy for pancreatic cancer, and a promising new target is phosphatidylserine (PS). PS is an anionic phospholipid normally located on the inner leaflet of the plasma membrane. Oxidative stress in the microenvironment of tumors causes PS exposure on the surface of endothelial cells. PS-positive endothelial cells are functional and not apoptotic. PS is absent from the endothelium of normal tissues, and is therefore a highly specific marker of tumor vessels. The antibody 3G4 binds PS and inhibits growth of a variety of tumors in mice. Here we highlight 3G4 as a treatment of pancreatic cancer in a mouse model. Inhibition of primary tumor growth and metastases at all sites was significant with 3G4 alone, and significantly enhanced by combination with gemcitabine. Thus, the combination of PS-targeting and gemcitabine might be an effective new drug combination for treatment of pancreatic cancer.
Original language | English (US) |
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Title of host publication | Vascular-Targeted Therapies in Oncology |
Publisher | John Wiley & Sons, Ltd |
Pages | 179-194 |
Number of pages | 16 |
ISBN (Print) | 9780470012949 |
DOIs | |
State | Published - May 31 2006 |
Keywords
- Combination therapy on metastasis
- Enhanced antitumor effect of combination therapy
- Inside-out phospholipids in pancreatic cancer
- PS exposure on tumor endothelium
- Pancreatic adenocarcinoma
- Phosphatidylserine (PS) - anionic phospholipid
- Vascular targeting
- Vascular-targeting agents (VTAs)
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology