Targeting NAD + Metabolism to Enhance Radiation Therapy Responses

Joshua E. Lewis, Naveen Singh, Reetta J. Holmila, Baran D Sumer, Noelle S Williams, Cristina M. Furdui, Melissa L. Kemp, David A Boothman

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Nicotinamide adenine dinucleotide (NAD + ) metabolism is integrally connected with the mechanisms of action of radiation therapy and is altered in many radiation-resistant tumors. This makes NAD + metabolism an ideal target for therapies that increase radiation sensitivity and improve patient outcomes. This review provides an overview of NAD + metabolism in the context of the cellular response to ionizing radiation, as well as current therapies that target NAD + metabolism to enhance radiation therapy responses. Additionally, we summarize state-of-the-art methods for measuring, modeling, and manipulating NAD + metabolism, which are being used to identify novel targets in the NAD + metabolic network for therapeutic interventions in combination with radiation therapy.

Original languageEnglish (US)
Pages (from-to)6-15
Number of pages10
JournalSeminars in Radiation Oncology
Volume29
Issue number1
DOIs
StatePublished - Jan 2019

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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