Targeting phenotypic heterogeneity in benign prostatic hyperplasia

Douglas W Strand, Daniel N Costa, Franto Francis, William A. Ricke, Claus Roehrborn

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Benign prostatic hyperplasia and associated lower urinary tract symptoms remain difficult to treat medically, resulting in hundreds of thousands of surgeries performed annually in elderly males. New therapies have not improved clinical outcomes since alpha blockers and 5 alpha reductase inhibitors were introduced in the 1990s. An underappreciated confounder to identifying novel targets is pathological heterogeneity. Individual patients display unique phenotypes, composed of distinct cell types. We have yet to develop a cellular or molecular understanding of these unique phenotypes, which has led to failure in developing targeted therapies for personalized medicine. This review covers the strategic experimental approach to unraveling the cellular pathogenesis of discrete BPH phenotypes and discusses how to incorporate these findings into the clinic to improve outcomes.

Original languageEnglish (US)
Pages (from-to)49-61
Number of pages13
JournalDifferentiation
Volume96
DOIs
StatePublished - Jul 1 2017

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology
  • Cancer Research

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