Targeting protein translation to prevent septic kidney injury

Research output: Contribution to journalReview article

Abstract

The development of acute kidney injury (AKI) in patients with sepsis causes significant morbidity and mortality. The pathogenesis of AKI in sepsis is incompletely understood. In this issue of the JCI, Hato et al. investigate the renal translatome during bacterial sepsis and identify the global shutdown of renal protein translation mediated by the eukaryotic translation initiation factor 2-α kinase 2/eukaryotic translation initiation factor 2α (EIF2AK2/ eIF2α) axis as a major pathway in mediating septic AKI. The results of this study suggest that inhibiting this pathway could be a potential therapeutic strategy for preventing septic AKI.

Original languageEnglish (US)
Article numberCI125432
JournalJournal of Clinical Investigation
Volume129
Issue number1
DOIs
StatePublished - Jan 2 2019

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Protein Biosynthesis
Acute Kidney Injury
Eukaryotic Initiation Factor-2
Eukaryotic Initiation Factors
Kidney
Sepsis
Wounds and Injuries
Phosphotransferases
Morbidity
Mortality
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Targeting protein translation to prevent septic kidney injury. / Huen, Sarah.

In: Journal of Clinical Investigation, Vol. 129, No. 1, CI125432, 02.01.2019.

Research output: Contribution to journalReview article

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