Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease

Nitin J. Karandikar, Carol L. Vanderlugt, Jeffrey A. Bluestone, Stephen D. Miller

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The B7/CD28:CTLA-4 costimulatory pathway plays a critical role in determining the fate of immmune responses (activation vs. down-regulation) and is a highly promising therapeutic target for treating autoimmune diseases. In this review, we highlight the mechanisms by which this costimulatory pathway operates emphasizing the role of the different components in the pathogenesis of relapsing experimental autoimmmune encephalomyelitis, a CD4 T cell-mediated autoimmune model of multiple sclerosis. The separate and distinct roles of B7-1, B7-2 and CTLA-4 in positive and negative regulation of autoimmune pathogenesis are considered and a working model is proposed.

Original languageEnglish (US)
Pages (from-to)10-18
Number of pages9
JournalJournal of Neuroimmunology
Volume89
Issue number1-2
DOIs
StatePublished - Aug 14 1998

Keywords

  • B7/CD28:CTLA-4 costimulatory system
  • Central nervous system (CNS)
  • Experimental autoimmune encephalomyelitis (EAE)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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