Targeting the bone marrow in waldenstrom macroglobulinemia

Irene M. Ghobrial; Zhang Yong; Liu Yang; Ngo Hai; Feda Azab; Antonio Sacco; Abdelkareem Azab; Patricia Maiso; Brittany Morgan; Phong Quang; Ghayas C. Issa; Xavier Leleu; Aldo M. Roccaro

doi:10.1016/j.clml.2011.03.022

Targeting the bone marrow in waldenstrom macroglobulinemia

Irene M. Ghobrial, Zhang Yong, Liu Yang, Ngo Hai, Feda Azab, Antonio Sacco, Abdelkareem Azab, Patricia Maiso, Brittany Morgan, Phong Quang, Ghayas C. Issa, Xavier Leleu, Aldo M. Roccaro

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Waldenstrom macroglobulinemia (WM) is a low-grade B-cell lymphoma characterized by widespread involvement of the bone marrow with lymphoplasmacytic cells. In approximately 20% of patients, the malignant clone also involves the lymph nodes and induces hepatosplenomegaly. The mechanisms by which the tumor cells home to the bone marrow and preferentially reside in the marrow niches are not fully elucidated. In this review, we examine the role of the bone marrow microenvironment in the regulation of cell growth, survival and cell dissemination in WM. We also summarize specific regulators of niche-dependent tumor proliferation in WM. These include chemokines, adhesion molecules, Src/PI3K/Akt/mTOR signaling, NF-kB activation, and micro-RNA regulation in WM. Targeting these pathways in clinical trials could lead to significant responses in this rare disease.

Original language	English (US)
Pages (from-to)	S65-S69
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	11
Issue number	SUPPL.1
DOIs	https://doi.org/10.1016/j.clml.2011.03.022
State	Published - Jun 2011
Externally published	Yes

Keywords

Adhesion
Bone marrow
Cell trafficking
Homing
Niche
Waldenstrom

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.clml.2011.03.022

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title = "Targeting the bone marrow in waldenstrom macroglobulinemia",

abstract = "Waldenstrom macroglobulinemia (WM) is a low-grade B-cell lymphoma characterized by widespread involvement of the bone marrow with lymphoplasmacytic cells. In approximately 20% of patients, the malignant clone also involves the lymph nodes and induces hepatosplenomegaly. The mechanisms by which the tumor cells home to the bone marrow and preferentially reside in the marrow niches are not fully elucidated. In this review, we examine the role of the bone marrow microenvironment in the regulation of cell growth, survival and cell dissemination in WM. We also summarize specific regulators of niche-dependent tumor proliferation in WM. These include chemokines, adhesion molecules, Src/PI3K/Akt/mTOR signaling, NF-kB activation, and micro-RNA regulation in WM. Targeting these pathways in clinical trials could lead to significant responses in this rare disease.",

keywords = "Adhesion, Bone marrow, Cell trafficking, Homing, Niche, Waldenstrom",

author = "Ghobrial, {Irene M.} and Zhang Yong and Liu Yang and Ngo Hai and Feda Azab and Antonio Sacco and Abdelkareem Azab and Patricia Maiso and Brittany Morgan and Phong Quang and Issa, {Ghayas C.} and Xavier Leleu and Roccaro, {Aldo M.}",

note = "Funding Information: Supported in part by the International Waldenstrom Macroglobulinemia Foundation, Kirsch Laboratory for Waldenstrom and Heje Fellowship for WM. ",

year = "2011",

month = jun,

doi = "10.1016/j.clml.2011.03.022",

language = "English (US)",

volume = "11",

pages = "S65--S69",

journal = "Clinical Lymphoma, Myeloma and Leukemia",

issn = "2152-2650",

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number = "SUPPL.1",

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TY - JOUR

T1 - Targeting the bone marrow in waldenstrom macroglobulinemia

AU - Ghobrial, Irene M.

AU - Yong, Zhang

AU - Yang, Liu

AU - Hai, Ngo

AU - Azab, Feda

AU - Sacco, Antonio

AU - Azab, Abdelkareem

AU - Maiso, Patricia

AU - Morgan, Brittany

AU - Quang, Phong

AU - Issa, Ghayas C.

AU - Leleu, Xavier

AU - Roccaro, Aldo M.

N1 - Funding Information: Supported in part by the International Waldenstrom Macroglobulinemia Foundation, Kirsch Laboratory for Waldenstrom and Heje Fellowship for WM.

PY - 2011/6

Y1 - 2011/6

N2 - Waldenstrom macroglobulinemia (WM) is a low-grade B-cell lymphoma characterized by widespread involvement of the bone marrow with lymphoplasmacytic cells. In approximately 20% of patients, the malignant clone also involves the lymph nodes and induces hepatosplenomegaly. The mechanisms by which the tumor cells home to the bone marrow and preferentially reside in the marrow niches are not fully elucidated. In this review, we examine the role of the bone marrow microenvironment in the regulation of cell growth, survival and cell dissemination in WM. We also summarize specific regulators of niche-dependent tumor proliferation in WM. These include chemokines, adhesion molecules, Src/PI3K/Akt/mTOR signaling, NF-kB activation, and micro-RNA regulation in WM. Targeting these pathways in clinical trials could lead to significant responses in this rare disease.

AB - Waldenstrom macroglobulinemia (WM) is a low-grade B-cell lymphoma characterized by widespread involvement of the bone marrow with lymphoplasmacytic cells. In approximately 20% of patients, the malignant clone also involves the lymph nodes and induces hepatosplenomegaly. The mechanisms by which the tumor cells home to the bone marrow and preferentially reside in the marrow niches are not fully elucidated. In this review, we examine the role of the bone marrow microenvironment in the regulation of cell growth, survival and cell dissemination in WM. We also summarize specific regulators of niche-dependent tumor proliferation in WM. These include chemokines, adhesion molecules, Src/PI3K/Akt/mTOR signaling, NF-kB activation, and micro-RNA regulation in WM. Targeting these pathways in clinical trials could lead to significant responses in this rare disease.

KW - Adhesion

KW - Bone marrow

KW - Cell trafficking

KW - Homing

KW - Niche

KW - Waldenstrom

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DO - 10.1016/j.clml.2011.03.022

M3 - Article

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VL - 11

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JO - Clinical Lymphoma, Myeloma and Leukemia

JF - Clinical Lymphoma, Myeloma and Leukemia

IS - SUPPL.1

ER -

Targeting the bone marrow in waldenstrom macroglobulinemia

Abstract

Keywords

ASJC Scopus subject areas

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