Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model

Chiatogu Onyewu, Emily Eads, Wiley A. Schell, John R. Perfect, Yehuda Ullmann, Gil Kaufman, Benjamin A. Horwitz, Israela Berdicevsky, Joseph Heitman

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Fluconazole-FK506 or fluconazole-cyclosporine drug combinations were tested in an ex vivo Trichophyton mentagrophytes human skin infection model. Conidia colonization was monitored by scanning electron microscopy over a 7-day treatment period. The fluconazole-FK506 combination demonstrated the most obvious advantage over single-drug therapy by clearing conidia and protecting skin from damage at low drug concentrations.

Original languageEnglish (US)
Pages (from-to)3743-3746
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number10
DOIs
StatePublished - Oct 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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