Targeting the vasculature of solid tumours

Philip E. Thorpe, Elaine J. Derbyshire

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Targeting cytotoxic agents or other effecters to vascular endothelial cells in solid tumours is an attractive new concept in cancer therapy. Killing these cells should initiate platelet aggregation and blood coagulation locally within the tumour vasculature, lending to tumour cell killing through starvation of oxygen and nutrients. In the present article, we review our progress in the development of this concept, from its validation in a mouse tumour model, to the identification of markers that might permit the selective attack of tumour vasculature in man.

Original languageEnglish (US)
Pages (from-to)277-288
Number of pages12
JournalJournal of Controlled Release
Volume48
Issue number2-3
DOIs
StatePublished - Oct 13 1997

Keywords

  • Cancer therapy
  • Endothelial cells
  • Immunotoxins
  • Solid tumours
  • Vascular targeting

ASJC Scopus subject areas

  • Pharmaceutical Science

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