Task force report: Future research needs for the prevention and management of immune-mediated drug hypersensitivity reactions

N. Franklin Adkinson, David Essayan, Rebecca Gruchalla, Helen Haggerty, Thomas Kawabata, J. David Sandler, Lawrence Updyke, Neil H. Shear, Daniel Wierda

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Immune-mediated drug hypersensitivity reactions (IDHR) have a significant impact on clinical practice, drug development, and public health. However, research to understand IDHR mechanisms and to develop diagnostic and predictive tests has been limited. To stimulate more research, a task force with representatives from the key stakeholders (research clinicians, regulatory scientists, and immunotoxicologists from the pharmaceutical industry) was assembled to identify critical data gaps and opportunities and to make recommendations on how to overcome some of the barriers to IDHR research and address research needs. It is hoped that this report will act as a springboard for future discussions and progress toward increased funding and development of organizational structures for IDHR research.

Original languageEnglish (US)
Pages (from-to)S461-S478
JournalJournal of Allergy and Clinical Immunology
Volume109
Issue number3
DOIs
StatePublished - Jan 1 2002

Keywords

  • Adverse drug reactions
  • Drug allergy
  • Drug development
  • Drug hypersensitivity
  • Immunotoxicology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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