Abstract
Immune-mediated drug hypersensitivity reactions (IDHR) have a significant impact on clinical practice, drug development, and public health. However, research to understand IDHR mechanisms and to develop diagnostic and predictive tests has been limited. To stimulate more research, a task force with representatives from the key stakeholders (research clinicians, regulatory scientists, and immunotoxicologists from the pharmaceutical industry) was assembled to identify critical data gaps and opportunities and to make recommendations on how to overcome some of the barriers to IDHR research and address research needs. It is hoped that this report will act as a springboard for future discussions and progress toward increased funding and development of organizational structures for IDHR research.
| Original language | English (US) |
|---|---|
| Journal | Journal of Allergy and Clinical Immunology |
| Volume | 109 |
| Issue number | 3 |
| State | Published - 2002 |
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Keywords
- Adverse drug reactions
- Drug allergy
- Drug development
- Drug hypersensitivity
- Immunotoxicology
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Task force report : Future research needs for the prevention and management of immune-mediated drug hypersensitivity reactions. / Adkinson, N. Franklin; Essayan, David; Gruchalla, Rebecca; Haggerty, Helen; Kawabata, Thomas; Sandler, J. David; Updyke, Lawrence; Shear, Neil H.; Wierda, Daniel.
In: Journal of Allergy and Clinical Immunology, Vol. 109, No. 3, 2002.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Task force report
T2 - Future research needs for the prevention and management of immune-mediated drug hypersensitivity reactions
AU - Adkinson, N. Franklin
AU - Essayan, David
AU - Gruchalla, Rebecca
AU - Haggerty, Helen
AU - Kawabata, Thomas
AU - Sandler, J. David
AU - Updyke, Lawrence
AU - Shear, Neil H.
AU - Wierda, Daniel
PY - 2002
Y1 - 2002
N2 - Immune-mediated drug hypersensitivity reactions (IDHR) have a significant impact on clinical practice, drug development, and public health. However, research to understand IDHR mechanisms and to develop diagnostic and predictive tests has been limited. To stimulate more research, a task force with representatives from the key stakeholders (research clinicians, regulatory scientists, and immunotoxicologists from the pharmaceutical industry) was assembled to identify critical data gaps and opportunities and to make recommendations on how to overcome some of the barriers to IDHR research and address research needs. It is hoped that this report will act as a springboard for future discussions and progress toward increased funding and development of organizational structures for IDHR research.
AB - Immune-mediated drug hypersensitivity reactions (IDHR) have a significant impact on clinical practice, drug development, and public health. However, research to understand IDHR mechanisms and to develop diagnostic and predictive tests has been limited. To stimulate more research, a task force with representatives from the key stakeholders (research clinicians, regulatory scientists, and immunotoxicologists from the pharmaceutical industry) was assembled to identify critical data gaps and opportunities and to make recommendations on how to overcome some of the barriers to IDHR research and address research needs. It is hoped that this report will act as a springboard for future discussions and progress toward increased funding and development of organizational structures for IDHR research.
KW - Adverse drug reactions
KW - Drug allergy
KW - Drug development
KW - Drug hypersensitivity
KW - Immunotoxicology
UR - http://www.scopus.com/inward/record.url?scp=0036128527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036128527&partnerID=8YFLogxK
M3 - Article
C2 - 11897992
AN - SCOPUS:0036128527
VL - 109
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 3
ER -