Taste novelty induces intracellular redistribution of NR2A and NR2B subunits of NMDA receptor in the insular cortex

Luis Núñez-Jaramillo, Beatriz Jimenez, Nadia Ramirez-Munguía, Ilse Delint-Ramírez, Claudio Luna-Illades, Ricardo Tapia, Federico Bermúdez-Rattoni

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19 Scopus citations

Abstract

Taste recognition memory is a process by which animals associate a taste previously experienced with its gastric consequences. Novel taste presentation induces in the insular cortex biochemical modifications that decrease after the taste becomes familiar. Here we show that, in this cortex, consumption of a novel taste produces an increase of the NR2A and NR2B subunits of the NMDA receptor in the detergent resistant membrane (DRM) fraction. This increase did not occur in the adjacent parietal cortex, was not due to a change in the total amount of protein, and is related with the novelty of the stimulus since it was reduced after the taste became familiar. Furthermore, NR2A and NR2B subunits increase in the DRM was blocked by the injection of a muscarinic acetylcholine receptor antagonist. These results suggest that modulation of NMDA receptors in the insular cortex through the increase of its NR2A and NR2B subunits in the DRM is involved in the taste memory formation via a cholinergic process.

Original languageEnglish (US)
Pages (from-to)116-122
Number of pages7
JournalBrain Research
Volume1215
DOIs
Publication statusPublished - Jun 18 2008

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Keywords

  • Detergent resistant membranes
  • Learning
  • Taste recognition memory

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Núñez-Jaramillo, L., Jimenez, B., Ramirez-Munguía, N., Delint-Ramírez, I., Luna-Illades, C., Tapia, R., & Bermúdez-Rattoni, F. (2008). Taste novelty induces intracellular redistribution of NR2A and NR2B subunits of NMDA receptor in the insular cortex. Brain Research, 1215, 116-122. https://doi.org/10.1016/j.brainres.2008.03.032