TB or not TB: How Mycobacterium tuberculosis may evade drug treatment

Errol C. Friedberg, Paula L. Fischhaber

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

In this issue of Cell, a study by Valerie Mizrahi and her colleagues (Boshoff et al., 2003) suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)139-140
Number of pages2
JournalCell
Volume113
Issue number2
DOIs
StatePublished - Apr 18 2003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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