TY - JOUR
T1 - Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation
AU - Bonte, Frederick J.
AU - Harris, Thomas S.
AU - Hynan, Linda S.
AU - Bigio, Eileen H.
AU - White, Charles L.
PY - 2006/7
Y1 - 2006/7
N2 - PURPOSE: The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias, with particular reference to Alzheimer disease. MATERIALS AND METHODS: Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 49 subjects were ultimately compared with neuropathologic study of the brain at autopsy. RESULTS: Sensitivity = 86.7% (68.4-95.6%, 95% confidence interval [CI]), specificity = 89.5% (65.5-98.2% CI), positive predictive value = 92.9% (75.0-98.8% CI), negative predictive value = 81% (57.4-93.7% CI), accuracy = 87.8% (74.5-94.9% CI), likelihood ratio = 8.23% (7.09-9.57% CI). CONCLUSIONS: Comparison is made with several other SPECT and PET series with histopathologic correlation. Brain blood flow SPECT is useful in the diagnosis and differential diagnosis of the dementias.
AB - PURPOSE: The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias, with particular reference to Alzheimer disease. MATERIALS AND METHODS: Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 49 subjects were ultimately compared with neuropathologic study of the brain at autopsy. RESULTS: Sensitivity = 86.7% (68.4-95.6%, 95% confidence interval [CI]), specificity = 89.5% (65.5-98.2% CI), positive predictive value = 92.9% (75.0-98.8% CI), negative predictive value = 81% (57.4-93.7% CI), accuracy = 87.8% (74.5-94.9% CI), likelihood ratio = 8.23% (7.09-9.57% CI). CONCLUSIONS: Comparison is made with several other SPECT and PET series with histopathologic correlation. Brain blood flow SPECT is useful in the diagnosis and differential diagnosis of the dementias.
KW - Brain SPECT with histopathologic correlation
KW - SPECT in Alzheimer disease
KW - SPECT in frontotemporal dementias
KW - SPECT in the dementias
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U2 - 10.1097/01.rlu.0000222736.81365.63
DO - 10.1097/01.rlu.0000222736.81365.63
M3 - Article
C2 - 16785801
AN - SCOPUS:33748146390
SN - 0363-9762
VL - 31
SP - 376
EP - 378
JO - Clinical nuclear medicine
JF - Clinical nuclear medicine
IS - 7
ER -