Tc-99m human serum albumin: A suitable agent for plasma volume measurements in man

S. S. Yang, E. L. Nickoloff, P. A. McIntyre, W. C. Maddrey, H. H. Mikesell, U. Scheffel, W. Kasecamp, N. P. MacAllister

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Abstract

In 16 patients we have carried out simultaneous plasma-volume measurements with human serum albumins tagged with Tc-99m (Tc99m HSA) and I-131 (I-131 HSA). The correlation coefficient was 0.987. Tc-99m HSA, prepared from kits that predictably yield high labeling efficiency (and thereby negligible amounts of TcO4-), is clearly a superior agent for repeat plasma volume determinations, because of its shorter half-life and the reduced radiation dose to the subject.

Original languageEnglish (US)
Pages (from-to)804-807
Number of pages4
JournalJournal of Nuclear Medicine
Volume19
Issue number7
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Yang, S. S., Nickoloff, E. L., McIntyre, P. A., Maddrey, W. C., Mikesell, H. H., Scheffel, U., Kasecamp, W., & MacAllister, N. P. (1978). Tc-99m human serum albumin: A suitable agent for plasma volume measurements in man. Journal of Nuclear Medicine, 19(7), 804-807.