TY - JOUR
T1 - Technetium-99m macroaggregated albumin
T2 - A new lung scanning agent
AU - Peterson, C. C.
AU - Bonte, F. J.
N1 - Funding Information:
In the preparation of Tcgsm MAA we have started with TcgSm labeled human serum albumin supplied by Nuclear Consultants Corporation and have used the method of WAGNER et ~1.~~)t o obtain aggregates. It has been our observation that this method is simpler and more reliable in yielding particles of predictable and acceptable size than is the technique described by TAPLIN.~~) Wagner’s method entails using a 0.1 per cent albumin solution and adjusting the pH to 5.5 + 0.5 using 0.2 N NaOH and 0.2 N HCl. The technetium-99m albuminate is supplied to us at a pH of approximately 3.0. After pH adjustment the solution is heated for 4 min at lOO”C, * This work was supported in part by USPHS Training Grant Tl CA 5136-04, and in part by USPHS Grant HE-05181-06.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1967/3
Y1 - 1967/3
N2 - Preliminary studies using macroaggregated human serum albumin tagged with technetium-99m for lung scanning in rabbits are very encouraging. No problems were encountered in the preparation of the Tc99m tagged macroaggregates, and, as might be predicted, the administration of the prepared macroaggregate suspension results in very selective localization of activity in the lungs and high counting rates. Because of the extremely favorable 6 hr half-life and low photon energy of this isotope, large doses may be used to provide a counting rate which will facilitate rapid scanning, while reducing total patient radiation exposure. For these reasons it appears that MAA tagged with Tc99m may be the preferred agent for lung scanning.
AB - Preliminary studies using macroaggregated human serum albumin tagged with technetium-99m for lung scanning in rabbits are very encouraging. No problems were encountered in the preparation of the Tc99m tagged macroaggregates, and, as might be predicted, the administration of the prepared macroaggregate suspension results in very selective localization of activity in the lungs and high counting rates. Because of the extremely favorable 6 hr half-life and low photon energy of this isotope, large doses may be used to provide a counting rate which will facilitate rapid scanning, while reducing total patient radiation exposure. For these reasons it appears that MAA tagged with Tc99m may be the preferred agent for lung scanning.
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U2 - 10.1016/0020-708X(67)90101-9
DO - 10.1016/0020-708X(67)90101-9
M3 - Article
C2 - 6029698
AN - SCOPUS:0014064167
VL - 18
SP - 201
EP - 202
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
IS - 3
ER -