Telomerase activity in hematopoietic cells is associated with self-renewal potential

Sean J. Morrison, Karen R. Prowse, Peter Ho, Irving L. Weissman

Research output: Contribution to journalArticle

312 Citations (Scopus)

Abstract

It has been proposed that the biological clock underlying the limited division potential of eukaryotic cells is telomere length. We assayed telomerase activity in single cells of the hematopoietic and immune systems. We examined hematopoietic stem cells at four stages of differentiation, lineage-committed progenitors, and mature myeloid and lymphoid cells. The frequency of telomerase-expressing cells within each population was proportional to the frequency of cells thought to have self-renewal potential. Among bone marrow hematopoietic stem cells, 70% exhibited detectable telomerase activity. The telomerase-expressing somatic cells observed in this study are not thought to be immortal, and expression was not correlated with cell cycle distribution or differentiation state. This study demonstrates that the developmental characteristic most consistently associated with telomerase expression is self-renewal potential.

Original languageEnglish (US)
Pages (from-to)207-216
Number of pages10
JournalImmunity
Volume5
Issue number3
DOIs
StatePublished - Sep 1996

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Telomerase
Hematopoietic Stem Cells
Lymphoid Progenitor Cells
Biological Clocks
Myeloid Progenitor Cells
Hematopoietic System
Telomere
Eukaryotic Cells
Cell Differentiation
Immune System
Cell Cycle
Bone Marrow
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Telomerase activity in hematopoietic cells is associated with self-renewal potential. / Morrison, Sean J.; Prowse, Karen R.; Ho, Peter; Weissman, Irving L.

In: Immunity, Vol. 5, No. 3, 09.1996, p. 207-216.

Research output: Contribution to journalArticle

Morrison, Sean J. ; Prowse, Karen R. ; Ho, Peter ; Weissman, Irving L. / Telomerase activity in hematopoietic cells is associated with self-renewal potential. In: Immunity. 1996 ; Vol. 5, No. 3. pp. 207-216.
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