Telomerase activity in human intestine

Eiso Hiyama, Keiko Hiyama, Naokuni Tatsumoto, Takashi Kodama, Jerry W. Shay, Takashi Yokoyama

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

In human somatic cells without the activity of telomerase, the ends of chromosomes consisting of the telomeric repeats TTAGGG progressively erode with each cell division. In germline and immortal cells telomerase activity maintains telomere length and thus compensates for the 'end-replication problem'. Progressive telomere shortening and reactivation of telomerase activity have been considered to be one of the key mechanisms in cellular senescence and immortalization. It has been shown that while most somatic cells do not have detectable telomerase activity, almost all cancers do have telomerase activity. Thus, detection of telomerase activity may have utility in the early diagnosis of cancer and may be a new target for therapeutic intervention. However, there is recent evidence that some cells of renewal tissues, such as hematopoietic cells and basal cells of the epidermis, have detectable telomerase activity. In the present study, we report detectable telomerase activity in normal human intestinal mucosa. This activity is localized to the lower third of each crypt and may be derived from intestinal stem cells. Since intestinal telomeric repeats are shorter in adults when compared to children, the telomerase activity in the intestine is insufficient to maintain telomere length but may be sufficient to provide extended proliferative capacity for such renewal tissues.

Original languageEnglish (US)
Pages (from-to)453-458
Number of pages6
JournalInternational Journal of Oncology
Volume9
Issue number3
StatePublished - Sep 1996

Fingerprint

Telomerase
Human Activities
Intestines
Telomere
Telomere Shortening
Cell Aging
Intestinal Mucosa
Early Detection of Cancer
Epidermis
Cell Division
Stem Cells
Chromosomes

Keywords

  • crypt
  • intestine
  • stem cells
  • telomerase
  • telomere

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hiyama, E., Hiyama, K., Tatsumoto, N., Kodama, T., Shay, J. W., & Yokoyama, T. (1996). Telomerase activity in human intestine. International Journal of Oncology, 9(3), 453-458.

Telomerase activity in human intestine. / Hiyama, Eiso; Hiyama, Keiko; Tatsumoto, Naokuni; Kodama, Takashi; Shay, Jerry W.; Yokoyama, Takashi.

In: International Journal of Oncology, Vol. 9, No. 3, 09.1996, p. 453-458.

Research output: Contribution to journalArticle

Hiyama, E, Hiyama, K, Tatsumoto, N, Kodama, T, Shay, JW & Yokoyama, T 1996, 'Telomerase activity in human intestine', International Journal of Oncology, vol. 9, no. 3, pp. 453-458.
Hiyama E, Hiyama K, Tatsumoto N, Kodama T, Shay JW, Yokoyama T. Telomerase activity in human intestine. International Journal of Oncology. 1996 Sep;9(3):453-458.
Hiyama, Eiso ; Hiyama, Keiko ; Tatsumoto, Naokuni ; Kodama, Takashi ; Shay, Jerry W. ; Yokoyama, Takashi. / Telomerase activity in human intestine. In: International Journal of Oncology. 1996 ; Vol. 9, No. 3. pp. 453-458.
@article{bbd4dbad64e54f2b9587c73ca901402c,
title = "Telomerase activity in human intestine",
abstract = "In human somatic cells without the activity of telomerase, the ends of chromosomes consisting of the telomeric repeats TTAGGG progressively erode with each cell division. In germline and immortal cells telomerase activity maintains telomere length and thus compensates for the 'end-replication problem'. Progressive telomere shortening and reactivation of telomerase activity have been considered to be one of the key mechanisms in cellular senescence and immortalization. It has been shown that while most somatic cells do not have detectable telomerase activity, almost all cancers do have telomerase activity. Thus, detection of telomerase activity may have utility in the early diagnosis of cancer and may be a new target for therapeutic intervention. However, there is recent evidence that some cells of renewal tissues, such as hematopoietic cells and basal cells of the epidermis, have detectable telomerase activity. In the present study, we report detectable telomerase activity in normal human intestinal mucosa. This activity is localized to the lower third of each crypt and may be derived from intestinal stem cells. Since intestinal telomeric repeats are shorter in adults when compared to children, the telomerase activity in the intestine is insufficient to maintain telomere length but may be sufficient to provide extended proliferative capacity for such renewal tissues.",
keywords = "crypt, intestine, stem cells, telomerase, telomere",
author = "Eiso Hiyama and Keiko Hiyama and Naokuni Tatsumoto and Takashi Kodama and Shay, {Jerry W.} and Takashi Yokoyama",
year = "1996",
month = "9",
language = "English (US)",
volume = "9",
pages = "453--458",
journal = "International Journal of Oncology",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "3",

}

TY - JOUR

T1 - Telomerase activity in human intestine

AU - Hiyama, Eiso

AU - Hiyama, Keiko

AU - Tatsumoto, Naokuni

AU - Kodama, Takashi

AU - Shay, Jerry W.

AU - Yokoyama, Takashi

PY - 1996/9

Y1 - 1996/9

N2 - In human somatic cells without the activity of telomerase, the ends of chromosomes consisting of the telomeric repeats TTAGGG progressively erode with each cell division. In germline and immortal cells telomerase activity maintains telomere length and thus compensates for the 'end-replication problem'. Progressive telomere shortening and reactivation of telomerase activity have been considered to be one of the key mechanisms in cellular senescence and immortalization. It has been shown that while most somatic cells do not have detectable telomerase activity, almost all cancers do have telomerase activity. Thus, detection of telomerase activity may have utility in the early diagnosis of cancer and may be a new target for therapeutic intervention. However, there is recent evidence that some cells of renewal tissues, such as hematopoietic cells and basal cells of the epidermis, have detectable telomerase activity. In the present study, we report detectable telomerase activity in normal human intestinal mucosa. This activity is localized to the lower third of each crypt and may be derived from intestinal stem cells. Since intestinal telomeric repeats are shorter in adults when compared to children, the telomerase activity in the intestine is insufficient to maintain telomere length but may be sufficient to provide extended proliferative capacity for such renewal tissues.

AB - In human somatic cells without the activity of telomerase, the ends of chromosomes consisting of the telomeric repeats TTAGGG progressively erode with each cell division. In germline and immortal cells telomerase activity maintains telomere length and thus compensates for the 'end-replication problem'. Progressive telomere shortening and reactivation of telomerase activity have been considered to be one of the key mechanisms in cellular senescence and immortalization. It has been shown that while most somatic cells do not have detectable telomerase activity, almost all cancers do have telomerase activity. Thus, detection of telomerase activity may have utility in the early diagnosis of cancer and may be a new target for therapeutic intervention. However, there is recent evidence that some cells of renewal tissues, such as hematopoietic cells and basal cells of the epidermis, have detectable telomerase activity. In the present study, we report detectable telomerase activity in normal human intestinal mucosa. This activity is localized to the lower third of each crypt and may be derived from intestinal stem cells. Since intestinal telomeric repeats are shorter in adults when compared to children, the telomerase activity in the intestine is insufficient to maintain telomere length but may be sufficient to provide extended proliferative capacity for such renewal tissues.

KW - crypt

KW - intestine

KW - stem cells

KW - telomerase

KW - telomere

UR - http://www.scopus.com/inward/record.url?scp=0029829887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029829887&partnerID=8YFLogxK

M3 - Article

C2 - 21541534

AN - SCOPUS:0029829887

VL - 9

SP - 453

EP - 458

JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

IS - 3

ER -