Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas

H. Tahara, T. Nakanishi, M. Kitamoto, R. Nakashio, J. W. Shay, E. Tahara, G. Kajiyama, T. Ide

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Abstract

Telomerase activity was examined in 105 frozen samples from human normal liver tissues, chronic liver disease, and hepatocellular carcinoma (HCC). Telomerase activity was positive in 28 of 33 HCC tissues regardless of tumor stage or size. Telomerase was expressed in 15 of 18 differentiated HCC nodules smaller than 3 cm. HCC tissues from all eight hepatitis B virus- positive patients were telomerase positive, while telomerase activity was not detected in normal liver tissues (0 of 4). Weak telomerase activity was only detected in 1 of 22 nontumor liver tissues from HCC patients. Interestingly, in 19 of 38 hepatitis tissues and 6 of 8 cirrhotic liver tissues from apparently cancer-free patients, very weak telomerase activity was detected. These results indicate that the expression of telomerase may play a crucial role in hepatocarcinogenesis.

Original languageEnglish (US)
Pages (from-to)2734-2736
Number of pages3
JournalCancer Research
Volume55
Issue number13
StatePublished - 1995

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Telomerase
Human Activities
Liver Diseases
Hepatocellular Carcinoma
Chronic Disease
Liver
Hepatitis B virus
Hepatitis
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Tahara, H., Nakanishi, T., Kitamoto, M., Nakashio, R., Shay, J. W., Tahara, E., ... Ide, T. (1995). Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas. Cancer Research, 55(13), 2734-2736.

Telomerase activity in human liver tissues : Comparison between chronic liver disease and hepatocellular carcinomas. / Tahara, H.; Nakanishi, T.; Kitamoto, M.; Nakashio, R.; Shay, J. W.; Tahara, E.; Kajiyama, G.; Ide, T.

In: Cancer Research, Vol. 55, No. 13, 1995, p. 2734-2736.

Research output: Contribution to journalArticle

Tahara, H, Nakanishi, T, Kitamoto, M, Nakashio, R, Shay, JW, Tahara, E, Kajiyama, G & Ide, T 1995, 'Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas', Cancer Research, vol. 55, no. 13, pp. 2734-2736.
Tahara, H. ; Nakanishi, T. ; Kitamoto, M. ; Nakashio, R. ; Shay, J. W. ; Tahara, E. ; Kajiyama, G. ; Ide, T. / Telomerase activity in human liver tissues : Comparison between chronic liver disease and hepatocellular carcinomas. In: Cancer Research. 1995 ; Vol. 55, No. 13. pp. 2734-2736.
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